Superiority of perfusion over bolus administration in cancer chemotherapy: proposition of a compartmental model.

Recent studies indicate that, for cancer chemotherapy, prolongation of drug injection time yields lower toxicity and better efficacy. We propose a compartmental pharmacological model to explain these observations. The model has been simulated on an analog computer. The curves obtained give a credible explanation for the clinical data. The superiority of perfusion over bolus injection may be attributed to plasma peak suppression.