OBJECTIVE: A higher prevalence of obesity in lower socioeconomic classes is common in Western societies. This study examined the role of gene-environment interactions in the association between parental education and body mass index (BMI) from infancy to the onset of adulthood. METHODS: Parentally reported BMI from 1 to 13 and self-reported BMI from 14 to 20 years of age were collected in 16,646 complete Dutch twin pairs and analyzed by genetic twin modeling. RESULTS: At 7 to 8 years of age, children whose parents had middle or low educational levels had more excess weight than the children of more highly educated parents, and the difference increased until 18 to 20 years of age. The major part of the BMI variation was explained by additive genetic factors (a(2) = 0.55-0.85), but environmental factors common for co-twins also played a significant role, especially from 3 to 7-8 years of age (c(2) = 0.15-0.29). The genetic variation in BMI was higher in children whose parents had middle or low educational levels compared with children whose parents had a high educational level. CONCLUSIONS: The interaction between genetic factors and the childhood social environment may contribute to the formation of socioeconomic differences in obesity.
OBJECTIVE: A higher prevalence of obesity in lower socioeconomic classes is common in Western societies. This study examined the role of gene-environment interactions in the association between parental education and body mass index (BMI) from infancy to the onset of adulthood. METHODS: Parentally reported BMI from 1 to 13 and self-reported BMI from 14 to 20 years of age were collected in 16,646 complete Dutch twin pairs and analyzed by genetic twin modeling. RESULTS: At 7 to 8 years of age, children whose parents had middle or low educational levels had more excess weight than the children of more highly educated parents, and the difference increased until 18 to 20 years of age. The major part of the BMI variation was explained by additive genetic factors (a(2) = 0.55-0.85), but environmental factors common for co-twins also played a significant role, especially from 3 to 7-8 years of age (c(2) = 0.15-0.29). The genetic variation in BMI was higher in children whose parents had middle or low educational levels compared with children whose parents had a high educational level. CONCLUSIONS: The interaction between genetic factors and the childhood social environment may contribute to the formation of socioeconomic differences in obesity.
Authors: K Komulainen; L Pulkki-Råback; M Jokela; L-P Lyytikäinen; N Pitkänen; T Laitinen; M Hintsanen; M Elovainio; T Hintsa; A Jula; M Juonala; K Pahkala; J Viikari; T Lehtimäki; O Raitakari; L Keltikangas-Järvinen Journal: Int J Obes (Lond) Date: 2017-07-31 Impact factor: 5.095
Authors: Karri Silventoinen; Aline Jelenkovic; Antti Latvala; Yoshie Yokoyama; Reijo Sund; Masumi Sugawara; Mami Tanaka; Satoko Matsumoto; Sari Aaltonen; Maarit Piirtola; Duarte L Freitas; José A Maia; Sevgi Y Öncel; Fazil Aliev; Fuling Ji; Feng Ning; Zengchang Pang; Esther Rebato; Kimberly J Saudino; Tessa L Cutler; John L Hopper; Vilhelmina Ullemar; Catarina Almqvist; Patrik K E Magnusson; Wendy Cozen; Amie E Hwang; Thomas M Mack; Gonneke Willemsen; Meike Bartels; Catharina E M van Beijsterveldt; Tracy L Nelson; Keith E Whitfield; Joohon Sung; Jina Kim; Jooyeon Lee; Sooji Lee; Clare H Llewellyn; Abigail Fisher; Emanuela Medda; Lorenza Nisticò; Virgilia Toccaceli; Laura A Baker; Catherine Tuvblad; Robin P Corley; Brooke M Huibregtse; Catherine A Derom; Robert F Vlietinck; Ruth J F Loos; Ariel Knafo-Noam; David Mankuta; Lior Abramson; S Alexandra Burt; Kelly L Klump; Judy L Silberg; Hermine H Maes; Robert F Krueger; Matt McGue; Shandell Pahlen; Margaret Gatz; David A Butler; Jennifer R Harris; Thomas S Nilsen; K Paige Harden; Elliot M Tucker-Drob; Carol E Franz; William S Kremen; Michael J Lyons; Paul Lichtenstein; Hoe-Uk Jeong; Yoon-Mi Hur; Dorret I Boomsma; Thorkild I A Sørensen; Jaakko Kaprio Journal: Obesity (Silver Spring) Date: 2019-04-05 Impact factor: 5.002
Authors: Alexis C Wood; Jacqueline M Blissett; Jeffrey M Brunstrom; Susan Carnell; Myles S Faith; Jennifer O Fisher; Laura L Hayman; Amrik Singh Khalsa; Sheryl O Hughes; Alison L Miller; Shabnam R Momin; Jean A Welsh; Jessica G Woo; Emma Haycraft Journal: J Am Heart Assoc Date: 2020-05-11 Impact factor: 5.501
Authors: Sarah Warkentin; Laís A Mais; Maria do Rosário Dias de Oliveira Latorre; Susan Carnell; José Augusto de Aguiar Carrazedo Taddei Journal: Front Nutr Date: 2018-08-10
Authors: Stephanie Schrempft; Cornelia H M van Jaarsveld; Abigail Fisher; Moritz Herle; Andrea D Smith; Alison Fildes; Clare H Llewellyn Journal: JAMA Pediatr Date: 2018-12-01 Impact factor: 16.193