Literature DB >> 27474676

pH responsive polyurethane (core) and cellulose acetate phthalate (shell) electrospun fibers for intravaginal drug delivery.

Dawei Hua1, Zhongche Liu1, Fang Wang1, Buhong Gao2, Fei Chen3, Qilu Zhang4, Ranhua Xiong5, Jingquan Han6, Sangram Keshari Samal7, Stefaan C De Smedt8, Chaobo Huang9.   

Abstract

In this study we present the use of co-axial electrospinning to produce core-shell composite micro-/nano- fibers of polyurethane (PU) and cellulose acetate phthalate (CAP). The designed fibers possess enhanced mechanical properties with a tensile strength of 13.27±2.32MPa, which is a clear improvement over the existing CAP fibers that suffer from a poor mechanical strength (0.2±0.03MPa). The CAP imparts pH responsiveness to the core-shell structure giving the fibers potential for "semen sensitive" (intravaginal) drug delivery.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cellulose acetate phthalate; Core-shell electrospinning; Intravaginal drug delivery; Polyurethane

Mesh：

Substances：

Year:  2016        PMID： 27474676     DOI： 10.1016/j.carbpol.2016.06.066

Source DB:  PubMed          Journal:  Carbohydr Polym        ISSN： 0144-8617            Impact factor:   9.381


  15 in total

1.  Sustained-release Griffithsin nanoparticle-fiber composites against HIV-1 and HSV-2 infections.

Authors:  Kevin M Tyo; Amanda B Lasnik; Longyun Zhang; Mohamed Mahmoud; Alfred B Jenson; Joshua L Fuqua; Kenneth E Palmer; Jill M Steinbach-Rankins
Journal:  J Control Release       Date:  2020-02-05       Impact factor: 9.776

2.  pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation.

Authors:  Syed Ahmed Shah; Muhammad Sohail; Muhammad Usman Minhas; Shahzeb Khan; Zahid Hussain; Arshad Mahmood; Mubeen Kousar; Asif Mahmood
Journal:  Drug Deliv Transl Res       Date:  2019-04       Impact factor: 4.617

Review 3.  Perspectives on Existing and Novel Alternative Intravaginal Probiotic Delivery Methods in the Context of Bacterial Vaginosis Infection.

Authors:  Priyadarshini Chandrashekhar; Farnaz Minooei; Wenndy Arreguin; Mohammadali Masigol; Jill M Steinbach-Rankins
Journal:  AAPS J       Date:  2021-05-10       Impact factor: 4.009

Review 4.  Relating Advanced Electrospun Fiber Architectures to the Temporal Release of Active Agents to Meet the Needs of Next-Generation Intravaginal Delivery Applications.

Authors:  Kevin M Tyo; Farnaz Minooei; Keegan C Curry; Sarah M NeCamp; Danielle L Graves; Joel R Fried; Jill M Steinbach-Rankins
Journal:  Pharmaceutics       Date:  2019-04-03       Impact factor: 6.321

Review 5.  Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S.

Authors:  Yaping Li; Lu An; Jiaomin Lin; Qiwei Tian; Shiping Yang
Journal:  Int J Nanomedicine       Date:  2019-07-24

Review 6.  Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters' roles.

Authors:  Graciela Lizeth Pérez-González; Luis Jesús Villarreal-Gómez; Aracely Serrano-Medina; Erick José Torres-Martínez; José Manuel Cornejo-Bravo
Journal:  Int J Nanomedicine       Date:  2019-07-15

7.  Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery.

Authors:  Liangyu Lu; Mengyu Ma; Chengtao Gao; Hongwei Li; Long Li; Fuping Dong; Yuzhu Xiong
Journal:  Pharmaceutics       Date:  2020-01-25       Impact factor: 6.321

Review 8.  Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy.

Authors:  Yongbing Sun; Wen Ma; Yuanyuan Yang; Mengxue He; Aimin Li; Lei Bai; Bin Yu; Zhiqiang Yu
Journal:  Asian J Pharm Sci       Date:  2019-06-12       Impact factor: 6.598

9.  In vitro Study on Synergistic Interactions Between Free and Encapsulated Q-Griffithsin and Antiretrovirals Against HIV-1 Infection.

Authors:  Farnaz Minooei; Joel R Fried; Joshua L Fuqua; Kenneth E Palmer; Jill M Steinbach-Rankins
Journal:  Int J Nanomedicine       Date:  2021-02-15

10.  Fabrication and Characterization of Polyetherimide Electrospun Scaffolds Modified with Graphene Nano-Platelets and Hydroxyapatite Nano-Particles.

Authors:  Vassilis Kostopoulos; Athanasios Kotrotsos; Kalliopi Fouriki; Alexandros Kalarakis; Diana Portan
Journal:  Int J Mol Sci       Date:  2020-01-16       Impact factor: 5.923
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