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Literature DB >> 274737

Specific antibody-dependent binding of complement component C1q to hapten-sensitized lipid vesicles.

Abstract

The binding of a component of human complement (C1q) to membrane-bound specific anti-nitroxide antibodies was studied as a function of the physical properties (fluid vs. solid) of vesicle lipids. The antibodies were bound to spin-label lipid haptens in the vesicle membrane. The binding of C1q to the sensitized vesicles shows a maximum as a function of specific IgG concentration. The binding of antibodies and of C1q to the vesicle membrane does not depend strongly on the physical state of the membrane lipids. even at low hapten (0.05 mol%) concentrations. These results are of significance for the understanding of the previously reported effect of lipid physical states on complement depletion.

Entities: Chemical Gene Species

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Year: 1978 PMID： 274737 PMCID： PMC411503 DOI： 10.1073/pnas.75.3.1515

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. Lateral hapten mobility and immunochemistry of model membranes.

Authors: P Brûlet; H M McConnell
Journal: Proc Natl Acad Sci U S A Date: 1976-09 Impact factor: 11.205

2. Large volume liposomes by an ether vaporization method.

Authors: D Deamer; A D Bangham
Journal: Biochim Biophys Acta Date: 1976-09-07

3. Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera.

Authors: K B Reid; D M Lowe; R R Porter
Journal: Biochem J Date: 1972-12 Impact factor: 3.857

4. Chemical studies of Clq; a modulator of immunoglobulin biology.

Authors: K Yonemasu; R M Stroud; W Niedermeier; W T Butler
Journal: Biochem Biophys Res Commun Date: 1971-06-18 Impact factor: 3.575

5. Binding properties of the human complement protein Clq.

Authors: C R Sledge; D H Bing
Journal: J Biol Chem Date: 1973-04-25 Impact factor: 5.157

6. Conformational changes and complement activation induced upon antigen binding to antibodies.

Authors: I Pecht; B Ehrenberg; E Calef; R Arnon
Journal: Biochem Biophys Res Commun Date: 1977-02-21 Impact factor: 3.575

7. Functional affinity constants of the reaction between 125I-labelled C1q and C1q binders and their use in the measurement of plasma C1q concentrations.

Authors: N C Hughes-Jones
Journal: Immunology Date: 1977-02 Impact factor: 7.397

8. The first complement component: evidence for an equilibrium between C1s free in serum and C1s bound in the C1 complex.

Authors: R M Bartholomew; A F Esser
Journal: J Immunol Date: 1977-12 Impact factor: 5.422

Specific antibody-dependent binding of complement component C1q to hapten-sensitized lipid vesicles.

1. Lateral hapten mobility and immunochemistry of model membranes.

2. Large volume liposomes by an ether vaporization method.

3. Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera.

4. Chemical studies of Clq; a modulator of immunoglobulin biology.

5. Binding properties of the human complement protein Clq.

6. Conformational changes and complement activation induced upon antigen binding to antibodies.

7. Functional affinity constants of the reaction between 125I-labelled C1q and C1q binders and their use in the measurement of plasma C1q concentrations.

8. The first complement component: evidence for an equilibrium between C1s free in serum and C1s bound in the C1 complex.

9. Membrane-controlled depletion of complement activity by spin-label-specific IgM.

10. Structural and dynamical aspects of membrane immunochemistry using model membranes.

1. Visualization of specific antibody and C1q binding to hapten-sensitized lipid vesicles.

2. Determination of molecular motion in membranes using periodic pattern photobleaching.

3. Optimal strategies in immunology III. The IgM-IgG switch.

4. TUNABLE COMPLEMENT ACTIVATION BY PARTICLES WITH VARIABLE SIZE AND Fc DENSITY.

5. Entrapment of a bacterial plasmid in phospholipid vesicles: potential for gene transfer.

6. The lateral diffusion of lipid probes in the surface membrane of Schistosoma mansoni.