Weiwei Ruan1, Jianping Zhong1, Ke Wang2, Guangyao Wu2, Yeqing Han1, Xianping Sun1, Chaohui Ye1, Xin Zhou1. 1. Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, P.R. China. 2. Department of Magnetic Resonance Imaging, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.
Abstract
PURPOSE: To demonstrate the feasibility to quantify the lung respiratory airway in vivo with hyperpolarized xenon diffusion magnetic resonance imaging (MRI), which is able to detect mild emphysema in the rat model. MATERIALS AND METHODS: The lung respiratory airways were quantified in vivo using hyperpolarized xenon diffusion MRI (7T) with eight b values (5, 10, 15, 20, 25, 30, 35, 40 s/cm2 ) in five control rats and five mild emphysematous rats, which were induced by elastase. The morphological results from histology were acquired and used for comparison. RESULTS: The parameters DL (longitudinal diffusion coefficient), r (internal radius), h (alveolar sleeve depth), Lm (mean linear intercept), and S/V (surface area to lung volume ratio) derived from the hyperpolarized xenon diffusion MRI in the emphysematous group showed significant differences from those in the control group (P < 0.05). Additionally, these parameters correlated well with the Lm obtained by the traditional histological sections (Pearson's correlation coefficients >0.8). CONCLUSION: The lung respiratory airways can be quantified by hyperpolarized xenon diffusion MRI, showing the potential for mild emphysema diagnosis. Also, the study suggested that the hyperpolarized xenon DL is more sensitive than DT (transverse diffusion coefficient) to detect mild emphysema. LEVEL OF EVIDENCE: 1 J. Magn. Reson. Imaging 2017;45:879-888.
PURPOSE: To demonstrate the feasibility to quantify the lung respiratory airway in vivo with hyperpolarized xenon diffusion magnetic resonance imaging (MRI), which is able to detect mild emphysema in the rat model. MATERIALS AND METHODS: The lung respiratory airways were quantified in vivo using hyperpolarized xenon diffusion MRI (7T) with eight b values (5, 10, 15, 20, 25, 30, 35, 40 s/cm2 ) in five control rats and five mild emphysematous rats, which were induced by elastase. The morphological results from histology were acquired and used for comparison. RESULTS: The parameters DL (longitudinal diffusion coefficient), r (internal radius), h (alveolar sleeve depth), Lm (mean linear intercept), and S/V (surface area to lung volume ratio) derived from the hyperpolarized xenon diffusion MRI in the emphysematous group showed significant differences from those in the control group (P < 0.05). Additionally, these parameters correlated well with the Lm obtained by the traditional histological sections (Pearson's correlation coefficients >0.8). CONCLUSION: The lung respiratory airways can be quantified by hyperpolarized xenon diffusion MRI, showing the potential for mild emphysema diagnosis. Also, the study suggested that the hyperpolarized xenon DL is more sensitive than DT (transverse diffusion coefficient) to detect mild emphysema. LEVEL OF EVIDENCE: 1 J. Magn. Reson. Imaging 2017;45:879-888.
Authors: Alexei V Ouriadov; Matthew S Fox; Andras A Lindenmaier; Elaine Stirrat; Hacene Serrai; Giles Santyr Journal: MAGMA Date: 2020-07-06 Impact factor: 2.310
Authors: Rohan S Virgincar; Jerry Dahlke; Scott H Robertson; Nathann Morand; Yi Qi; Simone Degan; Bastiaan Driehuys; John C Nouls Journal: J Magn Reson Date: 2018-07-23 Impact factor: 2.229