Brandon S Sheffield1. 1. From the Department of Pathology, Vancouver General Hospital, Vancouver, Canada.
Abstract
CONTEXT: -Molecular genetics is playing an increasingly important role in patient care and pathology practice. Immunohistochemistry (IHC) is a valuable and practical tool employed by most pathologists on a regular basis. OBJECTIVE: -To highlight select examples of how IHC may be used in the realm of molecular diagnostics. DATA SOURCES: -Select sources on IHC relating to tumor subtyping, hereditary cancer screening, and treatment-response prediction are reviewed. These represent some of the areas in which IHC can be employed by anatomic pathologists to optimize patient care and further inform molecular testing. CONCLUSION: -In the emerging era of personalized medicine, IHC continues to serve a valuable function, complementing and enhancing other molecular techniques.
CONTEXT: -Molecular genetics is playing an increasingly important role in patient care and pathology practice. Immunohistochemistry (IHC) is a valuable and practical tool employed by most pathologists on a regular basis. OBJECTIVE: -To highlight select examples of how IHC may be used in the realm of molecular diagnostics. DATA SOURCES: -Select sources on IHC relating to tumor subtyping, hereditary cancer screening, and treatment-response prediction are reviewed. These represent some of the areas in which IHC can be employed by anatomic pathologists to optimize patient care and further inform molecular testing. CONCLUSION: -In the emerging era of personalized medicine, IHC continues to serve a valuable function, complementing and enhancing other molecular techniques.
Authors: Elena Martínez-Terroba; Carmen Behrens; Fernando J de Miguel; Jackeline Agorreta; Eduard Monsó; Laura Millares; Cristina Sainz; Miguel Mesa-Guzman; José Luis Pérez-Gracia; María Dolores Lozano; Javier J Zulueta; Ruben Pio; Ignacio I Wistuba; Luis M Montuenga; María J Pajares Journal: J Pathol Date: 2018-06-20 Impact factor: 7.996
Authors: Christopher M Wilson; Oscar E Ospina; Mary K Townsend; Jonathan Nguyen; Carlos Moran Segura; Joellen M Schildkraut; Shelley S Tworoger; Lauren C Peres; Brooke L Fridley Journal: Cancers (Basel) Date: 2021-06-17 Impact factor: 6.575