Ana Fernández-Santander1, Apolonia Novillo1, María Gaibar1, Alicia Romero-Lorca1, Pedro Moral2,3, David Sánchez-Cuenca4, Nadir Amir5, Hassen Chaabani6, Nourdin Harich7, Maria Esther Esteban2,3. 1. Basic Biomedical Sciences Department, Universidad Europea de Madrid, Madrid, Spain. 2. Section of Zoology and Anthropology, Department of Evolutive Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain. 3. Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain. 4. Departamento de Genética, Antropología Física y Fisiología Animal (UPV/EHU), Leioa, Spain. 5. Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Algeria. 6. Faculty of Pharmacy, University of Monastir, Monastir, Tunisia. 7. Départément de Biologie, Faculté des Sciences, Université Chouaib Doukkali, El Jadida, Morocco.
Abstract
AIM: To describe the diversity of four cytochrome and four sulfotransferase polymorphisms in six north African samples. Scarce data have been compiled for these samples despite the rich genetic background of north African populations. MATERIALS & METHODS: CYP3A4*1B, CYP3A4*17, CYP3A4*3, CYP3A5*3, SULT1A1*2, SULT1A2*2, SULT1A2*3 and SULT1E1*2 polymorphisms were explored in 556 individuals from Morocco, Algeria, Tunisia and Libya. RESULTS: Allele frequencies in our samples largely exceeded the variation ranges described for European populations, especially for CYP3A4*1B, SULT1A1*2 and SULT1A2*3. CONCLUSION: North African populations are heterogeneous, genetically diverse and show a considerable sub-Saharan African contribution for markers associated with increased risk of prostate cancer and with differential drug metabolism.
AIM: To describe the diversity of four cytochrome and four sulfotransferase polymorphisms in six north African samples. Scarce data have been compiled for these samples despite the rich genetic background of north African populations. MATERIALS & METHODS:CYP3A4*1B, CYP3A4*17, CYP3A4*3, CYP3A5*3, SULT1A1*2, SULT1A2*2, SULT1A2*3 and SULT1E1*2 polymorphisms were explored in 556 individuals from Morocco, Algeria, Tunisia and Libya. RESULTS: Allele frequencies in our samples largely exceeded the variation ranges described for European populations, especially for CYP3A4*1B, SULT1A1*2 and SULT1A2*3. CONCLUSION: North African populations are heterogeneous, genetically diverse and show a considerable sub-Saharan African contribution for markers associated with increased risk of prostate cancer and with differential drug metabolism.
Entities:
Keywords:
cytochrome; genetic diversity; north African populations; sulfotransferase