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Literature DB >> 274716

Defective regulation of cholesterol biosynthesis and plasma membrane fluidity in a Chinese hamster ovary cell mutant.

Abstract

A Chinese hamster ovary cell mutant resistant to killing by 25-hydroxycholesterol is shown to be defective in the regulation of cholesterol synthesis by exogenous cholesterol. When grown with various cholesterol supplements in delipidized serum, the mutant cell exhibits a variation in cholesterol content and plasma membrane fluidity that is not observed in the parental cell type.

Entities: Chemical Species

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Year: 1978 PMID： 274716 PMCID： PMC411447 DOI： 10.1073/pnas.75.3.1247

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

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Journal: Can J Biochem Physiol Date: 1959-08

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Journal: Proc Natl Acad Sci U S A Date: 1965-02 Impact factor: 11.205

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Journal: Annu Rev Biochem Date: 1977 Impact factor: 23.643

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Authors: M Sinensky
Journal: Biochem Biophys Res Commun Date: 1977-10-10 Impact factor: 3.575

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Authors: S Schreier-Muccillo; D Marsh; H Dugas; H Schneider; C P Smith
Journal: Chem Phys Lipids Date: 1973-01 Impact factor: 3.329

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Authors: F R Landsberger; R W Compans
Journal: Biochemistry Date: 1976-06-01 Impact factor: 3.162

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Authors: M Sinensky
Journal: Proc Natl Acad Sci U S A Date: 1974-02 Impact factor: 11.205

7 in total

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Authors: M Sinensky; F Pinkerton; E Sutherland; F R Simon
Journal: Proc Natl Acad Sci U S A Date: 1979-10 Impact factor: 11.205

2. Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol.

Authors: J K Leighton; S Dueland; M S Straka; J Trawick; R A Davis
Journal: Mol Cell Biol Date: 1991-04 Impact factor: 4.272

6. Adaptive alteration in phospholipid composition of plasma membranes from a somatic cell mutant defective in the regulation of cholesterol biosynthesis.

Authors: M Sinensky
Journal: J Cell Biol Date: 1980-04 Impact factor: 10.539

7. Proton NMR visible mobile lipid signals in sensitive and multidrug-resistant K562 cells are modulated by rafts.

Authors: Aurélie Mannechez; Paiboon Reungpatthanaphong; Jacques D de Certaines; Geneviève Leray; Laurence Le Moyec
Journal: Cancer Cell Int Date: 2005-02-09 Impact factor: 5.722