Chien-Jung Chang1, Ya-Chu Chen2, Chih-Hsien Lee3, Ing-Fang Yang4, Ten-Fang Yang5. 1. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu; ; Division of Cardiology; 2. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu; 3. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu; ; Department of Cardiac Surgery, Tungs' Taichung Metroharbor Hospital, Taichung; 4. Department of Internal Medicine, Jen-Chi General Hospital; 5. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu; ; Graduate Institute of Medical Informatics, Department of Internal Medicine, Taipei Medical University and Hospital, Taipei, Taiwan.
Abstract
BACKGROUND: Heart rate variability (HRV) has been shown to be a useful measure of autonomic activity in healthy and mitral valve prolapsed (MVP) subjects. However, the effects of posture and gender on HRV in symptomatic MVP and normal adults had not been elucidated in Taiwan. METHODS: A total of 118 MVP patients (7 males, 39 ± 7 years old; and 111 females, 42 ± 13 years old) and 148 healthy control (54 males, 28 ± 4 years old; and 94 females, 26 ± 6 years old) were investigated. The diagnosis of MVP was confirmed by cross-sectional echocardiography. A locally developed Taiwanese machine was used to record the HRV parameters for MVP and control groups in three stationary positions. Thereafter, the HRV time-domain parameters, and the frequency-domain parameters derived from fast Fourier transform or autoregressive methods were analyzed. RESULTS: The MVP group showed a decrease in time domain parameters and obtunded postural effects on frequency domain parameters moreso than the control group. Though the parasympathetic tone was dominant in female (higher RMSSD, nHF and lower nLF vs. male), the sympathetic outflow was higher in MVP female (lower SDNN, NN50 and higher nLF vs. normal female). While the parasympathetic activity was lower in male, sympathetic outflow was dominant in MVP male (lower nHF and higher nLF vs. normal male). CONCLUSIONS: Both MVP female and male subjects had elevated levels of sympathetic outflow. The obtunded postural effects on frequency domain measures testified to the autonomic dysregulation of MVP subjects.
BACKGROUND: Heart rate variability (HRV) has been shown to be a useful measure of autonomic activity in healthy and mitral valve prolapsed (MVP) subjects. However, the effects of posture and gender on HRV in symptomatic MVP and normal adults had not been elucidated in Taiwan. METHODS: A total of 118 MVP patients (7 males, 39 ± 7 years old; and 111 females, 42 ± 13 years old) and 148 healthy control (54 males, 28 ± 4 years old; and 94 females, 26 ± 6 years old) were investigated. The diagnosis of MVP was confirmed by cross-sectional echocardiography. A locally developed Taiwanese machine was used to record the HRV parameters for MVP and control groups in three stationary positions. Thereafter, the HRV time-domain parameters, and the frequency-domain parameters derived from fast Fourier transform or autoregressive methods were analyzed. RESULTS: The MVP group showed a decrease in time domain parameters and obtunded postural effects on frequency domain parameters moreso than the control group. Though the parasympathetic tone was dominant in female (higher RMSSD, nHF and lower nLF vs. male), the sympathetic outflow was higher in MVP female (lower SDNN, NN50 and higher nLF vs. normal female). While the parasympathetic activity was lower in male, sympathetic outflow was dominant in MVP male (lower nHF and higher nLF vs. normal male). CONCLUSIONS: Both MVP female and male subjects had elevated levels of sympathetic outflow. The obtunded postural effects on frequency domain measures testified to the autonomic dysregulation of MVP subjects.
Authors: D D Savage; R J Garrison; R B Devereux; W P Castelli; S J Anderson; D Levy; P M McNamara; J Stokes; W B Kannel; M Feinleib Journal: Am Heart J Date: 1983-09 Impact factor: 4.749
Authors: S Strano; S De Castro; A Ferrucci; A Mazzei; C Urani; P Giannantoni; A Marcheselli; G Massimo Ciavarella; G Calcagnini; S Cerutti Journal: Cardiologia Date: 1992-11