Chun-Chieh Wang1, Hung-Yu Chang2, Wei-Hsian Yin2, Yen-Wen Wu3, Pao-Hsien Chu1, Chih-Cheng Wu4, Chih-Hsin Hsu5, Ming-Shien Wen1, Wen-Chol Voon6, Wei-Shiang Lin7, Jin-Long Huang8, Shyh-Ming Chen9, Ning-I Yang10, Heng-Chia Chang11, Kuan-Cheng Chang12, Shih-Hsien Sung13, Kou-Gi Shyu14, Jiunn-Lee Lin15, Guang-Yuan Mar16, Kuei-Chuan Chan17, Jen-Yuan Kuo18, Ji-Hung Wang19, Zhih-Cherng Chen20, Wei-Kung Tseng21, Wen-Jin Cherng10. 1. Division of Cardiology, Chang Gung Memorial Hospital, Linkou; 2. Heart Center, Cheng Hsin General Hospital, Taipei; 3. Cardiology Division of Cardiovascular Medical Center, Far Eastern memorial Hospital, New Taipei City; 4. Cardiovascular Center, National Taiwan University Hospital, Hsinchu Branch, Hsinchu; 5. Institute of Clinical Medicine, National Cheng Kung University, College of Medicine, and National Cheng Kung University Hospital, Tainan; 6. Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung; 7. Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei; 8. Cardiovascular Center, Taichung Veterans General Hospital, Taichung; 9. Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung; 10. Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung; 11. Division of Cardiology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City; 12. Division of Cardiovascular Medicine and Cardiovascular Research Laboratory, China Medical University Hospital, Taichung; 13. Division of Cardiology, Taipei Veterans General Hospital; 14. Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital; 15. Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei; 16. Division of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung; 17. Department of Internal Medicine, Chung-Shan Medical University Hospital, Taichung; 18. Division of Cardiology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei; 19. Division of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien; 20. Division of Cardiovascular Medicine, Chimei Medical Center, Tainan; 21. Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan.
Abstract
INTRODUCTION: Heart failure (HF) is a medical condition with a rapidly increasing incidence both in Taiwan and worldwide. The objective of the TSOC-HFrEF registry was to assess epidemiology, etiology, clinical management, and outcomes in a large sample of hospitalized patients presenting with acute decompensated systolic HF. METHODS: The TSOC-HFrEF registry was a prospective, multicenter, observational survey of patients presenting to 21 medical centers or teaching hospitals in Taiwan. Hospitalized patients with either acute new-onset HF or acute decompensation of chronic HFrEF were enrolled. Data including demographic characteristics, medical history, primary etiology of HF, precipitating factors for HF hospitalization, presenting symptoms and signs, diagnostic and treatment procedures, in-hospital mortality, length of stay, and discharge medications, were collected and analyzed. RESULTS: A total of 1509 patients were enrolled into the registry by the end of October 2014, with a mean age of 64 years (72% were male). Ischemic cardiomyopathy and dilated cardiomyopathy were diagnosed in 44% and 33% of patients, respectively. Coronary artery disease, hypertension, diabetes, and chronic renal insufficiency were the common comorbid conditions. Acute coronary syndrome, non-compliant to treatment, and concurrent infection were the major precipitating factors for acute decompensation. The median length of hospital stay was 8 days, and the in-hospital mortality rate was 2.4%. At discharge, 62% of patients were prescribed either angiotensin-converting enzyme-inhibitors or angiotensin receptor blockers, 60% were prescribed beta-blockers, and 49% were prescribed mineralocorticoid receptor antagonists. CONCLUSIONS: The TSOC-HFrEF registry provided important insights into the current clinical characteristics and management of hospitalized decompensated systolic HF patients in Taiwan. One important observation was that adherence to guideline-directed medical therapy was suboptimal.
INTRODUCTION:Heart failure (HF) is a medical condition with a rapidly increasing incidence both in Taiwan and worldwide. The objective of the TSOC-HFrEF registry was to assess epidemiology, etiology, clinical management, and outcomes in a large sample of hospitalized patients presenting with acute decompensated systolic HF. METHODS: The TSOC-HFrEF registry was a prospective, multicenter, observational survey of patients presenting to 21 medical centers or teaching hospitals in Taiwan. Hospitalized patients with either acute new-onset HF or acute decompensation of chronic HFrEF were enrolled. Data including demographic characteristics, medical history, primary etiology of HF, precipitating factors for HF hospitalization, presenting symptoms and signs, diagnostic and treatment procedures, in-hospital mortality, length of stay, and discharge medications, were collected and analyzed. RESULTS: A total of 1509 patients were enrolled into the registry by the end of October 2014, with a mean age of 64 years (72% were male). Ischemic cardiomyopathy and dilated cardiomyopathy were diagnosed in 44% and 33% of patients, respectively. Coronary artery disease, hypertension, diabetes, and chronic renal insufficiency were the common comorbid conditions. Acute coronary syndrome, non-compliant to treatment, and concurrent infection were the major precipitating factors for acute decompensation. The median length of hospital stay was 8 days, and the in-hospital mortality rate was 2.4%. At discharge, 62% of patients were prescribed either angiotensin-converting enzyme-inhibitors or angiotensin receptor blockers, 60% were prescribed beta-blockers, and 49% were prescribed mineralocorticoid receptor antagonists. CONCLUSIONS: The TSOC-HFrEF registry provided important insights into the current clinical characteristics and management of hospitalized decompensated systolic HFpatients in Taiwan. One important observation was that adherence to guideline-directed medical therapy was suboptimal.
Entities:
Keywords:
Beta-blocker; Guideline; Heart failure; Renin-angiotensin system blocker; Taiwan; Treatment
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