| Literature DB >> 27470400 |
Shifeng Chen1, Hong Wu1, Na Lv1, Hongling Wang1, Yushu Wang1, Qianqing Tang1, Huiyuan Shao1, Chengming Sun2.
Abstract
LncRNA colon cancer-associated transcript 2 (CCAT2) was firstly discovered and found overexpressed in colorectal cancer, and identified as is oncogenic lncRNA. However, the significance of CCAT2 in small cell lung cancer (SCLC) remains unclear. The expression of CCAT2 in SCLC tissues and cell lines was detected, and the association between CCAT2 expression and clinicopathological factors was analyzed. Cell proliferation and invasion assays were conducted by using SCLC cell lines transfected with CCAT2-siRNA or NC-siRNA. In our results, CCAT2 expression was elevated in SCLC tissues and cell lines, and correlated with malignant status and poor prognosis of SCLC patients. Furthermore, knockdown of CCAT2 expression effectively suppressed SCLC cell growth and metastasis in vitro. In conclusion, CCAT2 serves as an oncogenic lncRNA, and an independent unfavorable prognostic factor in SCLC patients.Entities:
Keywords: CCAT2; LncRNA; Metastasis; Proliferation; SCLC
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Year: 2016 PMID： 27470400 DOI： 10.1016/j.biopha.2016.05.017
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529