| Literature DB >> 27470129 |
Mehrnoush Moghaddasi1, Majid Taati2, Payman Asadian3, Ali Reza Khalatbary4, Raheleh Asaei5, Naser Pajouhi5.
Abstract
The purpose of this study was to evaluate the effects of cerebral hypoperfusion on cognitive ability, TNFα, IL1β and PGE2 levels in both hippocampi in a modified two-vessel occlusion model. Both common carotid arteries of adult male Wistar rats were permanently occluded with an interval of 1 week between occlusions. Learning and memory were significantly decreased after 1 month. This reduction was not significant after 2 months, which may be attributed to blood flow compensation. The TNFα level was significantly increased after 3 h and 1 day. IL1β was significantly increased after 1 day. After a week there was no significant difference in pro-inflammatory levels. Furthermore, there was no difference between right and left hippocampi. It is possible that TNFα and IL1β elevation initiates pathologic processes that contribute to memory impairment.Entities:
Keywords: Cerebral hypoperfusion; Hippocampus; Inflammation; Interleukins; Spatial memory
Mesh：
Substances：
Year: 2016 PMID： 27470129 DOI： 10.1007/s12576-016-0474-z
Source DB: PubMed Journal: J Physiol Sci ISSN： 1880-6546 Impact factor: 2.781