| Literature DB >> 27469128 |
Wael Zeinyeh1, Yannick J Esvan1, Lionel Nauton1, Nadège Loaëc2, Laurent Meijer2, Vincent Théry1, Fabrice Anizon1, Francis Giraud3, Pascale Moreau4.
Abstract
The synthesis of new diversely substituted pyrido[3,4-g]quinazolines is described. The inhibitory potencies of prepared compounds toward a panel of five CMGC protein kinases (CDK5, CLK1, DYRK1A, CK1, GSK3), that are known to play a potential role in Alzheimer's disease, were evaluated. The best overall kinase inhibition profile was found for nitro compound 4 bearing an ethyl group at the 5-position.Entities:
Keywords: CDK5; CK1; CLK1; DYRK1A; GSK3; Protein kinase inhibition; Pyrido[3,4-g]quinazoline
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Year: 2016 PMID： 27469128 DOI： 10.1016/j.bmcl.2016.07.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823