Literature DB >> 27468972

Daniel Bovet, Nobelist: muscle relaxants in anaesthesia : The role played by two neglected protagonists.

Dimitri A Cozanitis1.   

Abstract

In 1957, Professor Daniel Bovet received the Nobel Prize in Physiology or Medicine for his studies on various compounds including the muscle relaxants gallamine and succinylcholine that became very useful in anaesthesia. Textbooks credit Professor Bovet for the discovery of these drugs. However, although he indeed did discover their pharmacological character, the actual syntheses were made by Ernest Fourneau and Reid Hunt, respectively; sadly, these two scientists have largely been ignored. In this paper, a brief biography of Bovet is presented along with some of his more notable accomplishments. Particular emphasis has been placed on gallamine and succinylcholine along with their history. In an attempt to undo the "injustice" dealt to both Fourneau and Hunt, brief accounts of their history, story and character are provided.

Entities:  

Keywords:  20th century; Gallamine; History of medicine; Skeletal muscle relaxants; Succinylcholine

Mesh:

Substances:

Year:  2016        PMID: 27468972     DOI: 10.1007/s10354-016-0481-y

Source DB:  PubMed          Journal:  Wien Med Wochenschr        ISSN: 0043-5341


  14 in total

1.  Suxamethonium (succinylcholine) chloride and muscle pains.

Authors:  H C CHURCHILL-DAVIDSON
Journal:  Br Med J       Date:  1954-01-09

2.  Prolonged apnoea following injection of succinyldicholine.

Authors:  A FORBAT; H LEHMANN; E SILK
Journal:  Lancet       Date:  1953-11-21       Impact factor: 79.321

3.  [Not Available].

Authors:  J P Fourneau
Journal:  Rev Hist Pharm (Paris)       Date:  1987

4.  Curare-like action of polymethylene bis-quaternary ammonium salts.

Authors:  R B BARLOW; H R ING
Journal:  Nature       Date:  1948-05-08       Impact factor: 49.962

5.  Curarising properties of phenolic ethers with quaternary ammonium functions.

Authors:  D BOVET; F DEPIERRE; Y DE LESTRANGE
Journal:  C R Hebd Seances Acad Sci       Date:  1947-07-07

6.  Some aspects of the relationship between chemical constitution and curare-like activity.

Authors:  D BOVET
Journal:  Ann N Y Acad Sci       Date:  1951-10       Impact factor: 5.691

7.  A relaxant of very brief action.

Authors:  C F SCURR
Journal:  Br Med J       Date:  1951-10-06

8.  [Daniel Bovet. A student's testimonial].

Authors:  G Bignami
Journal:  Ann Ist Super Sanita       Date:  1993       Impact factor: 1.663

9.  [Daniel Bovet the teacher].

Authors:  B Silvestrini
Journal:  Ann Ist Super Sanita       Date:  1993       Impact factor: 1.663

10.  Preliminary trials of bistrimethylammonium decane and pentane diiodide (C10 and C5) in man.

Authors:  G ORGANE; W D M PATON; E J ZAIMIS
Journal:  Lancet       Date:  1949-01-01       Impact factor: 79.321

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