Literature DB >> 27467935

Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy.

C Bryce Johnson1, John Wrangle2, Shikhar Mehrotra1, Zihai Li2, Chrystal M Paulos3, David J Cole1, Charles D Surh4, Mark P Rubinstein3.   

Abstract

IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7Rα, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7Rα and rely on IL-7 for persistence and antitumor immunity.

Entities:  

Keywords:  Adoptive cellular therapy; CD8; IL-15; IL-7; IL-7Ra

Year:  2016        PMID： 27467935      PMCID： PMC4910714          DOI： 10.1080/2162402X.2015.1122865

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development.

Authors:  Kimberly D Klonowski; Kristina J Williams; Amanda L Marzo; Leo Lefrançois
Journal:  J Immunol       Date:  2006-10-01       Impact factor: 5.422

Review 2.  Adoptive immunotherapy for cancer: building on success.

Authors:  Luca Gattinoni; Daniel J Powell; Steven A Rosenberg; Nicholas P Restifo
Journal:  Nat Rev Immunol       Date:  2006-05       Impact factor: 53.106

3.  Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.

Authors:  Nikhil S Joshi; Weiguo Cui; Anmol Chandele; Heung Kyu Lee; David R Urso; James Hagman; Laurent Gapin; Susan M Kaech
Journal:  Immunity       Date:  2007-08       Impact factor: 31.745

Review 4.  Functions of γC cytokines in immune homeostasis: current and potential clinical applications.

Authors:  Willem W Overwijk; Kimberly S Schluns
Journal:  Clin Immunol       Date:  2009-05-09       Impact factor: 3.969

5.  Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.

Authors:  Mark E Dudley; James C Yang; Richard Sherry; Marybeth S Hughes; Richard Royal; Udai Kammula; Paul F Robbins; JianPing Huang; Deborah E Citrin; Susan F Leitman; John Wunderlich; Nicholas P Restifo; Armen Thomasian; Stephanie G Downey; Franz O Smith; Jacob Klapper; Kathleen Morton; Carolyn Laurencot; Donald E White; Steven A Rosenberg
Journal:  J Clin Oncol       Date:  2008-09-22       Impact factor: 44.544

6.  Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host.

Authors:  Mark P Rubinstein; Colleen A Cloud; Tracy E Garrett; Caitlin J Moore; Kristina M Schwartz; C Bryce Johnson; David H Craig; Mohamed L Salem; Chrystal M Paulos; David J Cole
Journal:  J Am Coll Surg       Date:  2012-02-22       Impact factor: 6.113

7.  Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Rα Dependent.

Authors:  C Bryce Johnson; Brian P Riesenberg; Bennett R May; Stuart C Gilreath; Guangfu Li; Kevin F Staveley-O'Carroll; Elizabeth Garrett-Mayer; Shikhar Mehrotra; David J Cole; Mark P Rubinstein
Journal:  Cancer Immunol Res       Date:  2015-08-21       Impact factor: 11.151

Review 8.  Homeostasis of memory T cells.

Authors:  Charles D Surh; Onur Boyman; Jared F Purton; Jonathan Sprent
Journal:  Immunol Rev       Date:  2006-06       Impact factor: 12.988

9.  Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells.

Authors:  Mark P Rubinstein; Ee Wern Su; Samantha Suriano; Colleen A Cloud; Kristina Andrijauskaite; Pravin Kesarwani; Kristina M Schwartz; Katelyn M Williams; C Bryce Johnson; Mingli Li; Gina M Scurti; Mohamed L Salem; Chrystal M Paulos; Elizabeth Garrett-Mayer; Shikhar Mehrotra; David J Cole
Journal:  Cancer Immunol Immunother       Date:  2015-02-13       Impact factor: 6.968

10.  Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

Authors:  Susan M Kaech; Joyce T Tan; E John Wherry; Bogumila T Konieczny; Charles D Surh; Rafi Ahmed
Journal:  Nat Immunol       Date:  2003-11-16       Impact factor: 25.606
  10 in total
  2 in total

Review 1.  New Developments in T Cell Immunometabolism and Implications for Cancer Immunotherapy.

Authors:  Nathaniel Oberholtzer; Kristen M Quinn; Paramita Chakraborty; Shikhar Mehrotra
Journal:  Cells       Date:  2022-02-17       Impact factor: 6.600

2.  Mesothelin-specific Immune Responses Predict Survival of Patients With Brain Metastasis.

Authors:  Liu Zhenjiang; Martin Rao; Xiaohua Luo; Elisabeth Sandberg; Jiri Bartek; Esther Schoutrop; Anna von Landenberg; Qingda Meng; Davide Valentini; Thomas Poiret; Georges Sinclair; Inti-Harvey Peredo; Ernest Dodoo; Markus Maeurer
Journal:  EBioMedicine       Date:  2017-08-30       Impact factor: 8.143
  2 in total

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