Literature DB >> 27467920

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function.

Ningyan Zhang1, Robert E Jordan1, Zhiqiang An1.   

Abstract

Immune suppression is recognized as a hallmark of cancer and this notion is largely based on studies on cellular immunity. Our recent studies have demonstrated a potential new mechanism of cancer suppression of immunity by impairment of antibody effector function mediated by proteolytic enzymes in the tumor microenvironment.

Entities:  

Keywords:  Antibody immunity; cancer immune evasion; single proteolytic cleavage of the IgG hinge; tumor microenvironment

Year:  2015        PMID： 27467920      PMCID： PMC4910702          DOI： 10.1080/2162402X.2015.1122861

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge.

Authors:  Thomas J Malia; Alexey Teplyakov; Randall J Brezski; Jinquan Luo; Michelle Kinder; Raymond W Sweet; Juan C Almagro; Robert E Jordan; Gary L Gilliland
Journal:  Proteins       Date:  2014-04-16

2.  A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies.

Authors:  Xuejun Fan; Randall J Brezski; Hui Deng; Pooja M Dhupkar; Yun Shi; Anneliese Gonzalez; Songlin Zhang; Michael Rycyzyn; William R Strohl; Robert E Jordan; Ningyan Zhang; Zhiqiang An
Journal:  Mol Cancer Ther       Date:  2014-12-31       Impact factor: 6.261

3.  Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages.

Authors:  Yun Shi; Xuejun Fan; Hui Deng; Randall J Brezski; Michael Rycyzyn; Robert E Jordan; William R Strohl; Quanming Zou; Ningyan Zhang; Zhiqiang An
Journal:  J Immunol       Date:  2015-03-20       Impact factor: 5.422

4.  Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid.

Authors:  Mary H Ryan; Diane Petrone; Jennifer F Nemeth; Evan Barnathan; Lars Björck; Robert E Jordan
Journal:  Mol Immunol       Date:  2007-12-21       Impact factor: 4.407

5.  Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity.

Authors:  Ningyan Zhang; Hui Deng; Xuejun Fan; Anneliese Gonzalez; Songlin Zhang; Randall J Brezski; Byung-Kwon Choi; Michael Rycyzyn; William Strohl; Robert Jordan; Zhiqiang An
Journal:  Clin Cancer Res       Date:  2015-07-29       Impact factor: 12.531

6.  Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.

Authors:  Randall J Brezski; Omid Vafa; Diane Petrone; Susan H Tam; Gordon Powers; Mary H Ryan; Jennifer L Luongo; Allison Oberholtzer; David M Knight; Robert E Jordan
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-07       Impact factor: 11.205

7.  Engineered protease-resistant antibodies with selectable cell-killing functions.

Authors:  Michelle Kinder; Allison R Greenplate; Katharine D Grugan; Keri L Soring; Katharine A Heeringa; Stephen G McCarthy; Gregory Bannish; Meredith Perpetua; Frank Lynch; Robert E Jordan; William R Strohl; Randall J Brezski
Journal:  J Biol Chem       Date:  2013-08-28       Impact factor: 5.157

8.  Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease.

Authors:  Paolo Biancheri; Randall J Brezski; Antonio Di Sabatino; Allison R Greenplate; Keri L Soring; Gino R Corazza; Klaartje B Kok; Laura Rovedatti; Anna Vossenkämper; Nadja Ahmad; Susanne A Snoek; Severine Vermeire; Paul Rutgeerts; Robert E Jordan; Thomas T MacDonald
Journal:  Gastroenterology       Date:  2015-07-11       Impact factor: 22.682

9.  A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.

Authors:  Xuejun Fan; Randall J Brezski; Ming Fa; Hui Deng; Allison Oberholtzer; Anneliese Gonzalez; William P Dubinsky; William R Strohl; Robert E Jordan; Ningyan Zhang; Zhiqiang An
Journal:  Breast Cancer Res       Date:  2012-08-08       Impact factor: 6.466

10.  An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions.

Authors:  Michelle Kinder; Allison R Greenplate; William R Strohl; Robert E Jordan; Randall J Brezski
Journal:  MAbs       Date:  2015       Impact factor: 5.857
  10 in total
  1 in total

1.  Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions.

Authors:  Xuejun Fan; Zihao Yuan; Yueshui Zhao; Wei Xiong; Hao-Ching Hsiao; Rahmawati Pare; Jianmin Ding; Ahmad Almosa; Kai Sun; Songlin Zhang; Robert E Jordan; Cheok Song Lee; Zhiqiang An; Ningyan Zhang
Journal:  Commun Biol       Date:  2022-09-14
  1 in total

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