Literature DB >> 27467919

Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors.

Reiner Strick1, Pamela L Strissel1, Stephen B Baylin2, Katherine B Chiappinelli2.   

Abstract

Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.

Entities:  

Keywords:  DNA methylation; IFN-signalling; TLR; dsRNA; endogeneous retrovirus (ERV); epigenetic therapy; immune checkpoints; innate immunity

Year:  2015        PMID： 27467919      PMCID： PMC4910697          DOI： 10.1080/2162402X.2015.1122160

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.

Authors:  David Roulois; Helen Loo Yau; Rajat Singhania; Yadong Wang; Arnavaz Danesh; Shu Yi Shen; Han Han; Gangning Liang; Peter A Jones; Trevor J Pugh; Catherine O'Brien; Daniel D De Carvalho
Journal:  Cell       Date:  2015-08-27       Impact factor: 41.582

2.  Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Authors:  Katherine B Chiappinelli; Pamela L Strissel; Alexis Desrichard; Huili Li; Christine Henke; Benjamin Akman; Alexander Hein; Neal S Rote; Leslie M Cope; Alexandra Snyder; Vladimir Makarov; Sadna Budhu; Sadna Buhu; Dennis J Slamon; Jedd D Wolchok; Drew M Pardoll; Matthias W Beckmann; Cynthia A Zahnow; Taha Merghoub; Taha Mergoub; Timothy A Chan; Stephen B Baylin; Reiner Strick
Journal:  Cell       Date:  2015-08-27       Impact factor: 41.582

Review 3.  Toll-like receptors: Activation, signalling and transcriptional modulation.

Authors:  Dominic De Nardo
Journal:  Cytokine       Date:  2015-04-03       Impact factor: 3.861

Review 4.  The history of Toll-like receptors - redefining innate immunity.

Authors:  Luke A J O'Neill; Douglas Golenbock; Andrew G Bowie
Journal:  Nat Rev Immunol       Date:  2013-05-17       Impact factor: 53.106

5.  The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.

Authors:  Annie M Bruns; George P Leser; Robert A Lamb; Curt M Horvath
Journal:  Mol Cell       Date:  2014-08-07       Impact factor: 17.970

6.  Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors.

Authors:  Philipp Yu; Wolger Lübben; Heike Slomka; Janine Gebler; Madlen Konert; Chengcong Cai; Luisa Neubrandt; Olivia Prazeres da Costa; Stephanie Paul; Sonja Dehnert; Karolin Döhne; Michael Thanisch; Silke Storsberg; Lisa Wiegand; Andreas Kaufmann; Marianne Nain; Leticia Quintanilla-Martinez; Sabrina Bettio; Barbara Schnierle; Larissa Kolesnikova; Stephan Becker; Markus Schnare; Stefan Bauer
Journal:  Immunity       Date:  2012-11-08       Impact factor: 31.745

Review 7.  Immune Checkpoint Blockade in Cancer Therapy.

Authors:  Michael A Postow; Margaret K Callahan; Jedd D Wolchok
Journal:  J Clin Oncol       Date:  2015-01-20       Impact factor: 44.544

8.  Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.

Authors:  Marina Caskey; François Lefebvre; Abdelali Filali-Mouhim; Mark J Cameron; Jean-Philippe Goulet; Elias K Haddad; Gaëlle Breton; Christine Trumpfheller; Sarah Pollak; Irina Shimeliovich; Angela Duque-Alarcon; Li Pan; Annette Nelkenbaum; Andres M Salazar; Sarah J Schlesinger; Ralph M Steinman; Rafick P Sékaly
Journal:  J Exp Med       Date:  2011-11-07       Impact factor: 14.307

9.  Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.

Authors:  Huili Li; Katherine B Chiappinelli; Angela A Guzzetta; Hariharan Easwaran; Ray-Whay Chiu Yen; Rajita Vatapalli; Michael J Topper; Jianjun Luo; Roisin M Connolly; Nilofer S Azad; Vered Stearns; Drew M Pardoll; Nancy Davidson; Peter A Jones; Dennis J Slamon; Stephen B Baylin; Cynthia A Zahnow; Nita Ahuja
Journal:  Oncotarget       Date:  2014-02-15

Review 10.  Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5.

Authors:  Stephanie Reikine; Jennifer B Nguyen; Yorgo Modis
Journal:  Front Immunol       Date:  2014-07-23       Impact factor: 7.561
  10 in total
  18 in total

Review 1.  Underlying mechanisms of HIV-1 latency.

Authors:  Bizhan Romani; Elham Allahbakhshi
Journal:  Virus Genes       Date:  2017-03-03       Impact factor: 2.332

2.  SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation.

Authors:  Eui Tae Kim; Kathryn L Roche; Katarzyna Kulej; Lynn A Spruce; Steven H Seeholzer; Donald M Coen; Felipe Diaz-Griffero; Eain A Murphy; Matthew D Weitzman
Journal:  Cell Rep       Date:  2019-07-09       Impact factor: 9.423

Review 3.  Combining epigenetic and immune therapy to overcome cancer resistance.

Authors:  Stephanie Gomez; Tomasz Tabernacki; Julie Kobyra; Paige Roberts; Katherine B Chiappinelli
Journal:  Semin Cancer Biol       Date:  2019-12-23       Impact factor: 15.707

4.  Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine.

Authors:  Myrna R Nahas; Dina Stroopinsky; Jacalyn Rosenblatt; Leandra Cole; Athalia R Pyzer; Eleni Anastasiadou; Anna Sergeeva; Adam Ephraim; Abigail Washington; Shira Orr; Malgorzata McMasters; Matthew Weinstock; Salvia Jain; Rebecca K Leaf; Haider Ghiasuddin; Maryam Rahimian; Jessica Liegel; Jeffrey J Molldrem; Frank Slack; Donald Kufe; David Avigan
Journal:  Br J Haematol       Date:  2019-03-03       Impact factor: 6.998

5.  A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist.

Authors:  Huju Chi; Yue Hao; Xia Wang; Li Tang; Yongqiang Deng; Xianxiong Chen; Feng Gao; Ou Sha; Guangyi Jin
Journal:  Cells       Date:  2022-06-21       Impact factor: 7.666

Review 6.  The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation.

Authors:  Florian Wolff; Michael Leisch; Richard Greil; Angela Risch; Lisa Pleyer
Journal:  Cell Commun Signal       Date:  2017-03-31       Impact factor: 5.712

7.  Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy.

Authors:  Markus Eckstein; Pamela Strissel; Reiner Strick; Veronika Weyerer; Ralph Wirtz; Carolin Pfannstiel; Adrian Wullweber; Fabienne Lange; Philipp Erben; Robert Stoehr; Simone Bertz; Carol Imanuel Geppert; Nicole Fuhrich; Helge Taubert; Sven Wach; Johannes Breyer; Wolfgang Otto; Maximilian Burger; Christian Bolenz; Bastian Keck; Bernd Wullich; Arndt Hartmann; Danijel Sikic
Journal:  J Immunother Cancer       Date:  2020-05       Impact factor: 13.751

Review 8.  Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine.

Authors:  Jake R Conway; Eric Kofman; Shirley S Mo; Haitham Elmarakeby; Eliezer Van Allen
Journal:  Genome Med       Date:  2018-11-29       Impact factor: 11.117

9.  Establishment of keratinocyte cell lines from human hair follicles.

Authors:  Tanja Wagner; Maria Gschwandtner; Agata Strajeriu; Adelheid Elbe-Bürger; Johannes Grillari; Regina Grillari-Voglauer; Georg Greiner; Bahar Golabi; Erwin Tschachler; Michael Mildner
Journal:  Sci Rep       Date:  2018-09-07       Impact factor: 4.379

Review 10.  Epigenetic Crosstalk between the Tumor Microenvironment and Ovarian Cancer Cells: A Therapeutic Road Less Traveled.

Authors:  Yuliya Klymenko; Kenneth P Nephew
Journal:  Cancers (Basel)       Date:  2018-08-30       Impact factor: 6.639
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