Panagiotis Fikatas1, Fritz Klein2, Andreas Andreou2, Rosa Bianca Schmuck2, Johann Pratschke2, Marcus Bahra2. 1. Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany panagiotis.fikatas@charite.de. 2. Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Abstract
BACKGROUND: The role of radical pancreatic surgery for metastatic lesions of renal cell carcinoma (RCC) remains unclear. PATIENTS AND METHODS: In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014. RESULTS: Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome. CONCLUSION: The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma. Copyright
BACKGROUND: The role of radical pancreatic surgery for metastatic lesions of renal cell carcinoma (RCC) remains unclear. PATIENTS AND METHODS: In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014. RESULTS:Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome. CONCLUSION: The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma. Copyright
Authors: Nirmish Singla; Zhiqun Xie; Ze Zhang; Ming Gao; Qurratulain Yousuf; Oreoluwa Onabolu; Tiffani McKenzie; Vanina Toffessi Tcheuyap; Yuanqing Ma; Jacob Choi; Renee McKay; Alana Christie; Oscar Reig Torras; Isaac A Bowman; Vitaly Margulis; Ivan Pedrosa; Christopher Przybycin; Tao Wang; Payal Kapur; Brian Rini; James Brugarolas Journal: JCI Insight Date: 2020-04-09
Authors: Norah Alayyaf; Abdullah Abdulaziz AlQatari; Amer Altalib; Abdullah Saleh AlQattan; Abdulwahab A Alshahrani Journal: Am J Case Rep Date: 2021-01-05