Mustafa Zelal Muallem1, Jalid Sehouli2, Jumana Almuheimid2, Rolf Richter2, Ralf Joukhadar3, Helmut Plett2. 1. Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany Mustafa-Zelal.Muallem@charite.de. 2. Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany. 3. Department for Obstetrics and Gynaecology, Julius-Maximilians-University Würzburg, School of Medicine, Würzburg, Germany.
Abstract
BACKGROUND/AIM: We aimed to identify the surgical-pathological risk factors separately for pelvic and para-aortic lymph nodes (LN) metastases in endometrial cancer (EC). PATIENTS AND METHODS: The study cohort consisted of 179 patients with first diagnosis of EC, who were operated in our Institution between 2007 and 2014. RESULTS: Pelvic and para-aortic LN dissection was performed in 115 patients (64.2%). The positive pelvic and para-aortic LN were diagnosed in 11.3% and 16.1% of cases, respectively. Patients with bad differentiated tumors (G3) showed about 5-times more risk to have affected LN. Deep infiltration of myometrium elevated the risk of pelvic LN infiltration 5 times and of para-aortic LN infiltration 14 times. G3, myometrial infiltration >50% and type II endometrial cancer correlated with a worse progression free survival (PFS) and overall survival (OS). CONCLUSION: Tumor grade and deep myometrial invasion were the only significant predictors of pelvic and para-aortic lymph node metastases. Copyright
BACKGROUND/AIM: We aimed to identify the surgical-pathological risk factors separately for pelvic and para-aortic lymph nodes (LN) metastases in endometrial cancer (EC). PATIENTS AND METHODS: The study cohort consisted of 179 patients with first diagnosis of EC, who were operated in our Institution between 2007 and 2014. RESULTS: Pelvic and para-aortic LN dissection was performed in 115 patients (64.2%). The positive pelvic and para-aortic LN were diagnosed in 11.3% and 16.1% of cases, respectively. Patients with bad differentiated tumors (G3) showed about 5-times more risk to have affected LN. Deep infiltration of myometrium elevated the risk of pelvic LN infiltration 5 times and of para-aortic LN infiltration 14 times. G3, myometrial infiltration >50% and type II endometrial cancer correlated with a worse progression free survival (PFS) and overall survival (OS). CONCLUSION: Tumor grade and deep myometrial invasion were the only significant predictors of pelvic and para-aortic lymph node metastases. Copyright