Jian-Fang Zhou1, Zhi-Yong Chen2, Shan-Ming Yang3, Jia-Zhen Chen3, Ling-Ye Zhou3, Ya-Fen Wang3, Gang Wang3, Xia-Jian Yu3, Wen-Hong Zhang2. 1. Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China. jianfangzhoucn@126.com. 2. Department of Infectious Diseases, The Affiliated Huashan Hospital of Fudan University, Shanghai, China. 3. Department of Infectious Diseases, Fenghua People's Hospital, Fenghua, Zhejiang Province, 315500, China.
Abstract
OBJECTIVE: To investigate the changes in lymphocyte subsets that are caused by infection with different pathogens in children with hand, foot, and mouth disease. METHODS: T lymphocyte subsets were measured in the patients' peripheral blood, and serum, throat swab, and fecal samples were tested for enterovirus. RESULTS: Fecal and throat swab samples exhibited similar positive detection rates, and were significantly more likely to be positive, compared to serum samples (P < 0.01). The EV71-positive group exhibited significantly lower CD4 + TM cell counts (QR: 1.058), compared to the CD4 + TM cell counts in the CoxA16-positive group (QR: 1.391; P < 0.05). CONCLUSIONS: Throat swab and fecal samples exhibited significantly higher positive detection rates, compared to serum samples. In addition, EV71-infected children exhibited significantly lower CD4+ T-cell counts, compared to CoxA16-infected children, which suggests that EV71 infection may be associated with a poorer prognosis.
OBJECTIVE: To investigate the changes in lymphocyte subsets that are caused by infection with different pathogens in children with hand, foot, and mouth disease. METHODS: T lymphocyte subsets were measured in the patients' peripheral blood, and serum, throat swab, and fecal samples were tested for enterovirus. RESULTS: Fecal and throat swab samples exhibited similar positive detection rates, and were significantly more likely to be positive, compared to serum samples (P < 0.01). The EV71-positive group exhibited significantly lower CD4 + TM cell counts (QR: 1.058), compared to the CD4 + TM cell counts in the CoxA16-positive group (QR: 1.391; P < 0.05). CONCLUSIONS: Throat swab and fecal samples exhibited significantly higher positive detection rates, compared to serum samples. In addition, EV71-infected children exhibited significantly lower CD4+ T-cell counts, compared to CoxA16-infected children, which suggests that EV71infection may be associated with a poorer prognosis.
Entities:
Keywords:
Clinical features; Hand-foot-and-mouth disease; T lymphocyte subsets in peripheral blood
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