L Kotanidis1,2, K Nikolettos3, S Petousis4, B Asimakopoulos5, E Chatzimitrou6, G Kolios7, N Nikolettos8,3. 1. Laboratory of Reproductive Physiology - In Vitro Fertilization, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. drkotanidis@gmail.com. 2. , Florou 22A Kordelio, 56334, Thessaloníki, Greece. drkotanidis@gmail.com. 3. Embryokosmogenesis IVF Unit, Alexandroupolis, Greece. 4. 3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloníki, Greece. 5. Laboratory of Physiology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. 6. 4th DYPE, Thessaloníki, Greece. 7. Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. 8. Laboratory of Reproductive Physiology - In Vitro Fertilization, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Abstract
AIM: To investigate the predictive value of anti-Mullerian hormone (AMH) and antral follicle count (AFC) on the final number of oocytes retrieved and the availability of embryos for cryopreservation in in vitro fertilization (IVF) cycles. PATIENTS AND METHODS: In this prospective study, one hundred and twenty women in their first IVF treatment were enrolled. The short stimulation agonist protocol was used for controlled ovarian hyperstimulation in all cases. Serum AMH levels were measured during the menstrual cycle preceding treatment. AFC was measured in cycle day 2, just before starting ovarian stimulation. RESULTS: A strong, positive correlation between AMH, AFC and the number of collected oocytes was found. The patients with available and suitable supplementary embryos for cryopreservation had higher levels of AMH and larger numbers of AFC. CONCLUSION: AMH and AFC appear to be valuable markers mainly for ovarian reserve and response to IVF treatment. Serum AMH levels and AFC are significantly associated with the number of retrieved oocytes. Also, a positive correlation with the availability of supernumerary embryos suitable for cryopreservation was observed.
AIM: To investigate the predictive value of anti-Mullerian hormone (AMH) and antral follicle count (AFC) on the final number of oocytes retrieved and the availability of embryos for cryopreservation in in vitro fertilization (IVF) cycles. PATIENTS AND METHODS: In this prospective study, one hundred and twenty women in their first IVF treatment were enrolled. The short stimulation agonist protocol was used for controlled ovarian hyperstimulation in all cases. Serum AMH levels were measured during the menstrual cycle preceding treatment. AFC was measured in cycle day 2, just before starting ovarian stimulation. RESULTS: A strong, positive correlation between AMH, AFC and the number of collected oocytes was found. The patients with available and suitable supplementary embryos for cryopreservation had higher levels of AMH and larger numbers of AFC. CONCLUSION:AMH and AFC appear to be valuable markers mainly for ovarian reserve and response to IVF treatment. Serum AMH levels and AFC are significantly associated with the number of retrieved oocytes. Also, a positive correlation with the availability of supernumerary embryos suitable for cryopreservation was observed.
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