Literature DB >> 27465396

Neurotoxicity of Ammonia.

Simo S Oja1, Pirjo Saransaari2, Esa R Korpi3.   

Abstract

Abnormal liver function has dramatic effects on brain functions. Hyperammonemia interferes profoundly with brain metabolism, astrocyte volume regulation, and in particular mitochondrial functions. Gene expression in the brain and excitatory and inhibitory neurotransmission circuits are also affected. Experiments with a number of pertinent animal models have revealed several potential mechanisms which could underlie the pathological phenomena occurring in hepatic encephalopathy.

Entities:  

Keywords:  Astrocytes; Glutamine-glutamate cycle; Hepatic encephalopathy; Mitochondria; N-methyl-D-aspartate receptors; Reactive oxygen species

Mesh：

Substances：

Year:  2016        PMID： 27465396     DOI： 10.1007/s11064-016-2014-x

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  104 in total

Review 1.  Oxidative stress in the pathogenesis of hepatic encephalopathy.

Authors:  M D Norenberg; A R Jayakumar; K V Rama Rao
Journal:  Metab Brain Dis       Date:  2004-12       Impact factor: 3.584

Review 2.  Brain edema in acute liver failure: can it be prevented? Can it be treated?

Authors:  Andres T Blei
Journal:  J Hepatol       Date:  2007-02-05       Impact factor: 25.083

3.  Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine.

Authors:  Renata Leke; Lasse K Bak; Malene Anker; Torun M Melø; Michael Sørensen; Susanne Keiding; Hendrik Vilstrup; Peter Ott; Luis V Portela; Ursula Sonnewald; Arne Schousboe; Helle S Waagepetersen
Journal:  Neurotox Res       Date:  2010-05-18       Impact factor: 3.911

4.  Ammonia increases nitric oxide, free Zn(2+), and metallothionein mRNA expression in cultured rat astrocytes.

Authors:  Carolin Kruczek; Boris Görg; Verena Keitel; Hans J Bidmon; Freimut Schliess; Dieter Häussinger
Journal:  Biol Chem       Date:  2011-12       Impact factor: 3.915

Review 5.  Altered glial-neuronal crosstalk: cornerstone in the pathogenesis of hepatic encephalopathy.

Authors:  Roger F Butterworth
Journal:  Neurochem Int       Date:  2010-03-27       Impact factor: 3.921

6.  Inhibition of glutamine transport into mitochondria protects astrocytes from ammonia toxicity.

Authors:  V B R Pichili; K V Rama Rao; A R Jayakumar; M D Norenberg
Journal:  Glia       Date:  2007-06       Impact factor: 7.452

Review 7.  Prevention of ammonia and glutamate neurotoxicity by carnitine: molecular mechanisms.

Authors:  Marta Llansola; Slaven Erceg; Mariluz Hernández-Viadel; Vicente Felipo
Journal:  Metab Brain Dis       Date:  2002-12       Impact factor: 3.584

8.  Nitroarginine, an inhibitor of nitric oxide synthetase, attenuates ammonia toxicity and ammonia-induced alterations in brain metabolism.

Authors:  E Kosenko; Y Kaminsky; E Grau; M D Miñana; S Grisolía; V Felipo
Journal:  Neurochem Res       Date:  1995-04       Impact factor: 3.996

9.  Hyperammonemia alters the modulation by different neurosteroids of the glutamate-nitric oxide-cyclic GMP pathway through NMDA- GABAA - or sigma receptors in cerebellum in vivo.

Authors:  Alba González-Usano; Omar Cauli; Ana Agustí; Vicente Felipo
Journal:  J Neurochem       Date:  2013-02-17       Impact factor: 5.372

10.  Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain.

Authors:  Y Itzhak; A Roig-Cantisano; R S Dombro; M D Norenberg
Journal:  Brain Res       Date:  1995-12-24       Impact factor: 3.252
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  17 in total

Review 1.  90 years of monoamine oxidase: some progress and some confusion.

Authors:  Keith F Tipton
Journal:  J Neural Transm (Vienna)       Date:  2018-04-10       Impact factor: 3.575

2.  Multifactorial non-cirrhotic hyperammonaemic encephalopathy.

Authors:  Katherine Elizabeth Triplett; Ronan Murray; Matthew Anstey
Journal:  BMJ Case Rep       Date:  2018-03-09

3.  Methamphetamine-induced lethal toxicity in zebrafish larvae.

Authors:  Yu Chen; Alexander S Wisner; Isaac T Schiefer; Frederick E Williams; F Scott Hall
Journal:  Psychopharmacology (Berl)       Date:  2022-10-21       Impact factor: 4.415

4.  Analysis of Risk Factors for Postoperative Delirium After Liver Transplantation.

Authors:  Junguo Chen; Hao Wang; Zhijun He; Ting Li
Journal:  Neuropsychiatr Dis Treat       Date:  2020-07-03       Impact factor: 2.570

5.  The effects of thymoquinone on memory impairment and inflammation in rats with hepatic encephalopathy induced by thioacetamide.

Authors:  Somayeh Hajipour; Alireza Sarkaki; Mahin Dianat; Mohammad Rashno; Laaya Sadat Khorsandi; Yaghoob Farbood
Journal:  Metab Brain Dis       Date:  2021-02-23       Impact factor: 3.584

6.  Ammonium chloride alters neuronal excitability and synaptic vesicle release.

Authors:  Roman M Lazarenko; Claire E DelBove; Claire E Strothman; Qi Zhang
Journal:  Sci Rep       Date:  2017-07-11       Impact factor: 4.379

7.  N-acetyl cysteine treatment preserves mitochondrial indices of functionality in the brain of hyperammonemic mice.

Authors:  Hamidreza Mohammadi; Abolfazl Sayad; Mohsen Mohammadi; Hossein Niknahad; Reza Heidari
Journal:  Clin Exp Hepatol       Date:  2020-05-30

8.  Ammonia-Induced Glial-Inflammaging.

Authors:  Larissa Daniele Bobermin; Ricardo Haack Amaral Roppa; Carlos-Alberto Gonçalves; André Quincozes-Santos
Journal:  Mol Neurobiol       Date:  2020-06-15       Impact factor: 5.682

9.  Ammonia-induced mitochondrial impairment is intensified by manganese co-exposure: relevance to the management of subclinical hepatic encephalopathy and cirrhosis-associated brain injury.

Authors:  Reza Heidari; Akram Jamshidzadeh; Mohammad Mehdi Ommati; Elaheh Rashidi; Forouzan Khodaei; Ala Sadeghi; Arghavan Hosseini; Hossein Niknahad
Journal:  Clin Exp Hepatol       Date:  2019-05-13

10.  Prospective associations of the infant gut microbiome and microbial function with social behaviors related to autism at age 3 years.

Authors:  Hannah E Laue; Susan A Korrick; Emily R Baker; Margaret R Karagas; Juliette C Madan
Journal:  Sci Rep       Date:  2020-09-23       Impact factor: 4.379
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