Morten Buhagen1, Anna Grønskag, Siri Fenstad Ragde, Bjørn Hilt. 1. Department of Occupational Medicine, St. Olavs University Hospital in Trondheim (Mr Buhagen, Dr Grønskag, Ms Ragde, Dr Hilt); and Department of General Practice and Community Medicine, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway (Mr Buhagen, Drs Grønskag, Hilt).
Abstract
OBJECTIVE: This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned. METHODS: The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE. RESULTS: During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was positively confirmed for 14 of the 17 incident cases. There is reason to assume that the remaining cases also had been exposed to TCE. CONCLUSIONS: The present study supports the view that TCE is a kidney carcinogen.
OBJECTIVE: This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned. METHODS: The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE. RESULTS: During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was positively confirmed for 14 of the 17 incident cases. There is reason to assume that the remaining cases also had been exposed to TCE. CONCLUSIONS: The present study supports the view that TCE is a kidney carcinogen.
Authors: Angeline S Andrew; Meifang Li; Xun Shi; Judy R Rees; Karen M Craver; Jonathan M Petali Journal: Int J Environ Res Public Health Date: 2022-01-06 Impact factor: 3.390