Victoria Gómez1, George Woodman2, Barham K Abu Dayyeh3. 1. Division of Gastroenterology, Mayo Clinic, Jacksonville, Florida, USA. 2. Midsouth Bariatrics, Memphis, Tennessee, USA. 3. Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.
Abstract
OBJECTIVE: The effects of intragastric balloon (IGB) therapy on gastric emptying (GE) and weight loss remain to be fully understood. The effects of IGB on GE were investigated in this study. METHODS: This was a single-center, randomized, controlled study in which subjects with obesity either underwent IGB placement or were matched controls. IGB was removed at 6 months. GE was measured at baseline and at weeks 0, 8, 16, 27, and 39. Percent total body weight loss (%TBWL) was measured at 6 and 12 months. RESULTS:Twenty-nine subjects with obesity were enrolled; 15 were randomized to IGB placement and 14 to control. Two subjects had the IGB removed early. At baseline, 1- and 2-h gastric retention values were comparable between the groups but increased in the IGB group at weeks 8 and 16 (during IGB treatment) and then returned to baseline levels at 27 and 39 weeks. A greater increase in gastric retention from baseline to 8 weeks was associated with higher %TBWL. CONCLUSIONS:GE in subjects with IGB is delayed but returns to normal after IGB removal. Greater changes in increased gastric retention were associated with greater %TBWL. Altering gastric motility is a significant mechanism of action by which the IGB results in weight loss.
RCT Entities:
OBJECTIVE: The effects of intragastric balloon (IGB) therapy on gastric emptying (GE) and weight loss remain to be fully understood. The effects of IGB on GE were investigated in this study. METHODS: This was a single-center, randomized, controlled study in which subjects with obesity either underwent IGB placement or were matched controls. IGB was removed at 6 months. GE was measured at baseline and at weeks 0, 8, 16, 27, and 39. Percent total body weight loss (%TBWL) was measured at 6 and 12 months. RESULTS: Twenty-nine subjects with obesity were enrolled; 15 were randomized to IGB placement and 14 to control. Two subjects had the IGB removed early. At baseline, 1- and 2-h gastric retention values were comparable between the groups but increased in the IGB group at weeks 8 and 16 (during IGB treatment) and then returned to baseline levels at 27 and 39 weeks. A greater increase in gastric retention from baseline to 8 weeks was associated with higher %TBWL. CONCLUSIONS: GE in subjects with IGB is delayed but returns to normal after IGB removal. Greater changes in increased gastric retention were associated with greater %TBWL. Altering gastric motility is a significant mechanism of action by which the IGB results in weight loss.
Authors: Eric J Vargas; Carl M Pesta; Ahmad Bali; Eric Ibegbu; Fateh Bazerbachi; Rachel L Moore; Vivek Kumbhari; Reem Z Sharaiha; Trace W Curry; Gina DosSantos; Ramsey Schmitz; Abhishek Agnihotri; Aleksey A Novikov; Tracy Pitt; Margo K Dunlap; Andrea Herr; Louis Aronne; Erin Ledonne; Hoda C Kadouh; Lawrence J Cheskin; Manpreet S Mundi; Andres Acosta; Christopher J Gostout; Barham K Abu Dayyeh Journal: Clin Gastroenterol Hepatol Date: 2018-02-07 Impact factor: 11.382
Authors: Nitin Kumar; Fateh Bazerbachi; Tarun Rustagi; Thomas R McCarty; Christopher C Thompson; Manoel P Galvao Neto; Natan Zundel; Erik B Wilson; Christopher J Gostout; Barham K Abu Dayyeh Journal: Obes Surg Date: 2017-09 Impact factor: 4.129