| Literature DB >> 27464748 |
Jeffrey M Bender1, Fan Li2, Shoria Martelly3, Erin Byrt4, Vanessa Rouzier3, Marguerite Leo3, Nicole Tobin2, Pia S Pannaraj1, Helty Adisetiyo2, Adrienne Rollie2, Chintda Santiskulvong2, Shaun Wang5, Chloe Autran6, Lars Bode6, Daniel Fitzgerald7, Louise Kuhn5, Grace M Aldrovandi8.
Abstract
More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.Entities:
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Year: 2016 PMID： 27464748 PMCID： PMC5301310 DOI： 10.1126/scitranslmed.aaf5103
Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956