Literature DB >> 27464689

Respiratory Syncytial Virus (RSV): Neutralizing Antibody, a Correlate of Immune Protection.

Pedro A Piedra1,2,3, Anne M Hause4,5, Letisha Aideyan4.   

Abstract

Assays that measure RSV-specific neutralizing antibody activity are very useful for evaluating vaccine candidates, performing seroprevalence studies, and detecting infection. Neutralizing antibody activity is normally measured by a plaque reduction neutralization assay or by a microneutralization assay with or without complement. These assays measure the functional capacity of serum (or other fluids) to neutralize virus infectivity in cells as compared to ELISA assays that only measure the binding capacity against an antigen. This chapter discusses important elements in standardization of the RSV-specific microneutralization assay for use in the laboratory.

Entities:  

Keywords:  Microneutralization assay; Neutralization assay; Neutralizing antibodies

Mesh：

Substances：

Year:  2016        PMID： 27464689     DOI： 10.1007/978-1-4939-3687-8_7

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  6 in total

Review 1.  Establishing Correlates of Protection for Vaccine Development: Considerations for the Respiratory Syncytial Virus Vaccine Field.

Authors:  Prasad S Kulkarni; Julia L Hurwitz; Eric A F Simões; Pedro A Piedra
Journal:  Viral Immunol       Date:  2018-01-16       Impact factor: 2.257

2.  A prospective surveillance study on the kinetics of the humoral immune response to the respiratory syncytial virus fusion protein in adults in Houston, Texas.

Authors:  Brittani N Blunck; Letisha Aideyan; Xunyan Ye; Vasanthi Avadhanula; Laura Ferlic-Stark; Lynn Zechiedrich; Brian E Gilbert; Pedro A Piedra
Journal:  Vaccine       Date:  2021-01-26       Impact factor: 3.641

3.  Antigenic Site-Specific Competitive Antibody Responses to the Fusion Protein of Respiratory Syncytial Virus Were Associated With Viral Clearance in Hematopoietic Cell Transplantation Adults.

Authors:  Xunyan Ye; Obinna P Iwuchukwu; Vasanthi Avadhanula; Letisha O Aideyan; Trevor J McBride; Laura L Ferlic-Stark; Kirtida D Patel; Felipe-Andres Piedra; Dimpy P Shah; Roy F Chemaly; Pedro A Piedra
Journal:  Front Immunol       Date:  2019-03-29       Impact factor: 7.561

4.  Adult Memory T Cell Responses to the Respiratory Syncytial Virus Fusion Protein During a Single RSV Season (2018-2019).

Authors:  Brittani N Blunck; Laura S Angelo; David Henke; Vasanthi Avadhanula; Matthew Cusick; Laura Ferlic-Stark; Lynn Zechiedrich; Brian E Gilbert; Pedro A Piedra
Journal:  Front Immunol       Date:  2022-03-29       Impact factor: 8.786

5.  Longitudinal study of the immune response and memory following natural bovine respiratory syncytial virus infections in cattle of different age.

Authors:  Sara Hägglund; Katarina Näslund; Anna Svensson; Cecilia Lefverman; Hakan Enül; Leonore Pascal; Jari Siltenius; Menno Holzhauer; Alexis Delabouglise; Julia Österberg; Karin Alvåsen; Ulf Olsson; Jean-François Eléouët; Sabine Riffault; Geraldine Taylor; María Jose Rodriguez; Marga Garcia Duran; Jean François Valarcher
Journal:  PLoS One       Date:  2022-09-16       Impact factor: 3.752

6.  Humoral and Mucosal Antibody Response to RSV Structural Proteins in RSV-Infected Adult Hematopoietic Cell Transplant (HCT) Recipients.

Authors:  Xunyan Ye; Obinna P Iwuchukwu; Vasanthi Avadhanula; Letisha O Aideyan; Trevor J McBride; David M Henke; Kirtida D Patel; Felipe-Andres Piedra; Laura S Angelo; Dimpy P Shah; Roy F Chemaly; Pedro A Piedra
Journal:  Viruses       Date:  2021-05-26       Impact factor: 5.048
  6 in total

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