Literature DB >> 27464254

The influence of tissue microenvironment on stem cell-based cartilage repair.

Chathuraka T Jayasuriya1,2, Yupeng Chen1,2, Wenguang Liu2, Qian Chen1,2.   

Abstract

Mesenchymal stem/progenitor cells and induced pluripotent stem cells have become viable cell sources for prospective cell-based cartilage engineering and tissue repair. The development and function of stem cells are influenced by the tissue microenvironment. Specifically, the local tissue microenvironment can dictate how stem cells integrate into the existing tissue matrix and how successfully they can restore function to the damaged area in question. This review focuses on the microenvironmental features of articular cartilage and how they influence stem cell-based cartilage tissue repair. Also discussed are current tissue-engineering strategies used in combination with cell-based therapies, all of which are designed to mimic the natural properties of cartilage tissue in order to achieve a better healing response.
© 2016 New York Academy of Sciences.

Entities:  

Keywords:  articular cartilage; cartilage repair; chondroprogenitor; microenvironment; progenitor; stem cells

Mesh:

Year:  2016        PMID: 27464254      PMCID: PMC5599120          DOI: 10.1111/nyas.13170

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN: 0077-8923            Impact factor:   5.691


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