| Literature DB >> 27464254 |
Chathuraka T Jayasuriya1,2, Yupeng Chen1,2, Wenguang Liu2, Qian Chen1,2.
Abstract
Mesenchymal stem/progenitor cells and induced pluripotent stem cells have become viable cell sources for prospective cell-based cartilage engineering and tissue repair. The development and function of stem cells are influenced by the tissue microenvironment. Specifically, the local tissue microenvironment can dictate how stem cells integrate into the existing tissue matrix and how successfully they can restore function to the damaged area in question. This review focuses on the microenvironmental features of articular cartilage and how they influence stem cell-based cartilage tissue repair. Also discussed are current tissue-engineering strategies used in combination with cell-based therapies, all of which are designed to mimic the natural properties of cartilage tissue in order to achieve a better healing response.Entities:
Keywords: articular cartilage; cartilage repair; chondroprogenitor; microenvironment; progenitor; stem cells
Mesh:
Year: 2016 PMID: 27464254 PMCID: PMC5599120 DOI: 10.1111/nyas.13170
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN: 0077-8923 Impact factor: 5.691