Literature DB >> 27463376

Strategies in the discovery of novel antifungal scaffolds.

Na Liu1, Chen Wang2, Hua Su3, Wannian Zhang1, Chunquan Sheng1.   

Abstract

The development of next-generation antifungal agents with novel chemical scaffolds and new mechanisms of action is vital due to increased incidence and mortality of invasive fungal infections and severe drug resistance. This review will summarize current strategies to discover novel antifungal scaffolds. In particular, high-throughput screening, drug repurposing, antifungal natural products and new antifungal targets are focused on. New scaffolds with validated antifungal activity, their discovery and optimization process as well as structure-activity relationships are discussed in detail. Perspectives that could inspire future antifungal drug discovery are provided.

Entities:  

Keywords:  antifungal drug resistance; antifungal lead compounds; drug repurposing; fungal biofilm inhibitors; invasive fungal infections; new antifungal scaffolds; strategies in antifungal drug discovery

Mesh：

Substances：

Year:  2016        PMID： 27463376     DOI： 10.4155/fmc-2016-0020

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  9 in total

Review 1.  The antifungal pipeline: a reality check.

Authors:  John R Perfect
Journal:  Nat Rev Drug Discov       Date:  2017-05-12       Impact factor: 84.694

Review 2.  Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications.

Authors:  Ángel Serrano-Aroca; Alba Cano-Vicent; Roser Sabater I Serra; Mohamed El-Tanani; AlaaAA Aljabali; Murtaza M Tambuwala; Yogendra Kumar Mishra
Journal:  Mater Today Bio       Date:  2022-08-30

3.  Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis.

Authors:  Haroon Mohammad; Nehal H Elghazawy; Hassan E Eldesouky; Youssef A Hegazy; Waleed Younis; Larisa Avrimova; Tony Hazbun; Reem K Arafa; Mohamed N Seleem
Journal:  ACS Infect Dis       Date:  2018-02-02       Impact factor: 5.084

Review 4.  Targeting the GPI biosynthetic pathway.

Authors:  Usha Yadav; Mohd Ashraf Khan
Journal:  Pathog Glob Health       Date:  2018-02-27       Impact factor: 2.894

Review 5.  One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy.

Authors:  Erika Seki Kioshima; Patrícia de Souza Bonfim de Mendonça; Marcus de Melo Teixeira; Isis Regina Grenier Capoci; André Amaral; Franciele Abigail Vilugron Rodrigues-Vendramini; Bruna Lauton Simões; Ana Karina Rodrigues Abadio; Larissa Fernandes Matos; Maria Sueli Soares Felipe
Journal:  J Fungi (Basel)       Date:  2021-02-02

Review 6.  Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis.

Authors:  Liliana Scorzoni; Ana C A de Paula E Silva; Caroline M Marcos; Patrícia A Assato; Wanessa C M A de Melo; Haroldo C de Oliveira; Caroline B Costa-Orlandi; Maria J S Mendes-Giannini; Ana M Fusco-Almeida
Journal:  Front Microbiol       Date:  2017-01-23       Impact factor: 5.640

7.  Anticapsular and Antifungal Activity of α-Cyperone.

Authors:  Connor Horn; Govindsamy Vediyappan
Journal:  Antibiotics (Basel)       Date:  2021-01-06

8.  Identification of two potential inhibitors of Sporothrix brasiliensis and Sporothrix schenckii in the Pathogen Box collection.

Authors:  Luana Pereira Borba-Santos; Taissa Vila; Sonia Rozental
Journal:  PLoS One       Date:  2020-10-14       Impact factor: 3.240

9.  A New Antifungal Agent (4-phenyl-1, 3-thiazol-2-yl) Hydrazine Induces Oxidative Damage in Candida albicans.

Authors:  Quan-Zhen Lv; Ting-Jun-Hong Ni; Li-Ping Li; Tian Li; Da-Zhi Zhang; Yuan-Ying Jiang
Journal:  Front Cell Infect Microbiol       Date:  2020-10-07       Impact factor: 5.293
  9 in total

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