Gulsaz Shamim1, Sanjeev Kumar Ranjan2, Dev Mani Pandey3, Kewal Krishan Sharma2, Rangnathan Ramani2. 1. Department of Biotechnology, Birla Institute of Technology, Mesra; Lac Production Division, Indian Institute of Natural Resins and Gums, Namkum, Ranchi, Jharkhand, India. 2. Lac Production Division, Indian Institute of Natural Resins and Gums, Namkum, Ranchi, Jharkhand, India. 3. Department of Biotechnology, Birla Institute of Technology, Mesra, India.
Abstract
OBJECTIVE: Certain anthraquinone compounds are effectively used for treatment of cancer. The present study describes the inhibitory activity of lac dye, a mixture of polyhydroxy anthraquinone compounds (Laccaic acid A, B, C, D and E), produced by the Indian lac insect, Kerria lacca (Kerr). MATERIALS AND METHODS: In vitro testing for anticancer activity of lac dye was done at four concentrations (10, 20, 40, 80 μg/ml) on ten human malignant cell lines including six human leukemia cell lines, U973, Raji, K562, Jurkat, MOLT 4 and HL60 using SRB assay. RESULTS AND CONCLUSION: Both crimson and yellow lac dye inhibits proliferation of Human leukemia cell lines, Raji, U937, K562, HL60 and Jurkat, therefore can be considered as a potential anticancer agent for leukemia.
OBJECTIVE: Certain anthraquinone compounds are effectively used for treatment of cancer. The present study describes the inhibitory activity of lac dye, a mixture of polyhydroxy anthraquinone compounds (Laccaic acid A, B, C, D and E), produced by the Indian lac insect, Kerria lacca (Kerr). MATERIALS AND METHODS: In vitro testing for anticancer activity of lac dye was done at four concentrations (10, 20, 40, 80 μg/ml) on ten human malignant cell lines including six humanleukemia cell lines, U973, Raji, K562, Jurkat, MOLT 4 and HL60 using SRB assay. RESULTS AND CONCLUSION: Both crimson and yellow lac dye inhibits proliferation of Humanleukemia cell lines, Raji, U937, K562, HL60 and Jurkat, therefore can be considered as a potential anticancer agent for leukemia.