Vandana Puri1, Manjula Jain2, Gunjan Mahajan2, Mukta Pujani3. 1. Department of Pathology, University College of Medical Sciences and GTB Hospital, New Delhi, India. 2. Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India. 3. Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
Abstract
BACKGROUND: Fibroepithelial lesions of the breast are classified into fibroadenoma and phyllodes tumor (PT). Although WHO has established a well-defined grading system for PT, dilemma of discriminating borderline from malignant PT still exists. Stromal CD10 is a known poor prognostic factor in invasive breast cancer, its expression in fibroepithelial lesions of the breast is not well-documented. Till date, only one study has correlated the CD10 staining score with tumor grade in PT. OBJECTIVE: To evaluate whether the differences in expression patterns of CD10 and staining intensity correlate with the degree of malignancy in fibroepithelial tumors of the breast. MATERIALS AND METHODS: This is a retrospective study in which stromal CD10 expression was studied in 75 cases of fibroepithelial lesions of the breast using immunohistochemistry. Statistical analysis was performed using Chi-square test. RESULTS: There was a statistically significant trend of increasing stromal expression of CD10 with increasing degree of malignancy (P = 0.001). CONCLUSIONS: CD10 staining pattern and its scoring can assist the pathologist to accurately grade the PT of the breast for adequate treatment and can also be used as a target for the development of novel therapies.
BACKGROUND:Fibroepithelial lesions of the breast are classified into fibroadenoma and phyllodes tumor (PT). Although WHO has established a well-defined grading system for PT, dilemma of discriminating borderline from malignant PT still exists. Stromal CD10 is a known poor prognostic factor in invasive breast cancer, its expression in fibroepithelial lesions of the breast is not well-documented. Till date, only one study has correlated the CD10 staining score with tumor grade in PT. OBJECTIVE: To evaluate whether the differences in expression patterns of CD10 and staining intensity correlate with the degree of malignancy in fibroepithelial tumors of the breast. MATERIALS AND METHODS: This is a retrospective study in which stromal CD10 expression was studied in 75 cases of fibroepithelial lesions of the breast using immunohistochemistry. Statistical analysis was performed using Chi-square test. RESULTS: There was a statistically significant trend of increasing stromal expression of CD10 with increasing degree of malignancy (P = 0.001). CONCLUSIONS:CD10 staining pattern and its scoring can assist the pathologist to accurately grade the PT of the breast for adequate treatment and can also be used as a target for the development of novel therapies.
Authors: Wayne A Warner; Vandana Devika Sookdeo; Maurice Fortuné; Meenakshi Akhilesh; Chalapathi Rao Adidam Venkata; Wayne Mohammed; Cassandra Ramkissoon; Dave Harnanan; Lemuel Pran; Ravi Maharaj Journal: Int J Surg Case Rep Date: 2017-10-04