Literature DB >> 27461000

Immune Response Signaling: Combinatorial and Dynamic Control.

Alexander Hoffmann1.   

Abstract

Macrophages mount complex responses to pathogens. Although several key signaling pathways have been identified, it remains unclear how they work together to provide specificity. In a recent paper, Gottschalk et al. report that differential dose-response behaviors of the NFκB and MAPK pathways allow dose-specific gene expression programs.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27461000      PMCID： PMC5003693          DOI： 10.1016/j.it.2016.07.003

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  10 in total

1.  Tunable signal processing through a kinase control cycle: the IKK signaling node.

Authors:  Marcelo Behar; Alexander Hoffmann
Journal:  Biophys J       Date:  2013-07-02       Impact factor: 4.033

2.  Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation.

Authors:  Zhang Cheng; Brooks Taylor; Diana R Ourthiague; Alexander Hoffmann
Journal:  Sci Signal       Date:  2015-07-14       Impact factor: 8.192

3.  Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

Authors:  Rachel A Gottschalk; Andrew J Martins; Bastian R Angermann; Bhaskar Dutta; Caleb E Ng; Stefan Uderhardt; John S Tsang; Iain D C Fraser; Martin Meier-Schellersheim; Ronald N Germain
Journal:  Cell Syst       Date:  2016-05-26       Impact factor: 10.304

4.  Information transduction capacity of noisy biochemical signaling networks.

Authors:  Raymond Cheong; Alex Rhee; Chiaochun Joanne Wang; Ilya Nemenman; Andre Levchenko
Journal:  Science       Date:  2011-09-15       Impact factor: 47.728

5.  Stimulus specificity of gene expression programs determined by temporal control of IKK activity.

Authors:  Shannon L Werner; Derren Barken; Alexander Hoffmann
Journal:  Science       Date:  2005-09-16       Impact factor: 47.728

6.  Systems biology. Accurate information transmission through dynamic biochemical signaling networks.

Authors:  Jangir Selimkhanov; Brooks Taylor; Jason Yao; Anna Pilko; John Albeck; Alexander Hoffmann; Lev Tsimring; Roy Wollman
Journal:  Science       Date:  2014-12-12       Impact factor: 47.728

7.  Ultrasensitivity in the mitogen-activated protein kinase cascade.

Authors:  C Y Huang; J E Ferrell
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

Review 8.  A comprehensive map of the toll-like receptor signaling network.

Authors:  Kanae Oda; Hiroaki Kitano
Journal:  Mol Syst Biol       Date:  2006-04-18       Impact factor: 11.429

9.  Network dynamics determine the autocrine and paracrine signaling functions of TNF.

Authors:  Andrew B Caldwell; Zhang Cheng; Jesse D Vargas; Harry A Birnbaum; Alexander Hoffmann
Journal:  Genes Dev       Date:  2014-10-01       Impact factor: 11.361

10.  High-Content Quantification of Single-Cell Immune Dynamics.

Authors:  Michael Junkin; Alicia J Kaestli; Zhang Cheng; Christian Jordi; Cem Albayrak; Alexander Hoffmann; Savaş Tay
Journal:  Cell Rep       Date:  2016-03-31       Impact factor: 9.423
  10 in total
  5 in total

Review 1.  Stimulus-specific responses in innate immunity: Multilayered regulatory circuits.

Authors:  Stefanie Luecke; Katherine M Sheu; Alexander Hoffmann
Journal:  Immunity       Date:  2021-09-14       Impact factor: 43.474

2.  Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression.

Authors:  Supriya Sen; Zhang Cheng; Katherine M Sheu; Yu Hsin Chen; Alexander Hoffmann
Journal:  Cell Syst       Date:  2020-01-22       Impact factor: 10.304

Review 3.  NFκB and Kidney Injury.

Authors:  Ning Song; Friedrich Thaiss; Linlin Guo
Journal:  Front Immunol       Date:  2019-04-16       Impact factor: 7.561

4.  Immune Differentiation Regulator p100 Tunes NF-κB Responses to TNF.

Authors:  Budhaditya Chatterjee; Payel Roy; Uday Aditya Sarkar; Mingming Zhao; Yashika Ratra; Amit Singh; Meenakshi Chawla; Supriyo De; James Gomes; Ranjan Sen; Soumen Basak
Journal:  Front Immunol       Date:  2019-05-07       Impact factor: 7.561

5.  Information transmission from NFkB signaling dynamics to gene expression.

Authors:  Alok Maity; Roy Wollman
Journal:  PLoS Comput Biol       Date:  2020-08-14       Impact factor: 4.475
  5 in total

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