Literature DB >> 27460253

Sickle Cell Imaging Flow Cytometry Assay (SIFCA).

Kleber Y Fertrin1,2, Leigh Samsel3, Eduard J van Beers4, Laurel Mendelsohn5, Gregory J Kato6, J Philip McCoy7.   

Abstract

Hemoglobin S polymerization under hypoxic conditions in sickle cell disorders causes characteristic shape changes to human red blood cells. Previous sickling assays used to investigate the efficacy of novel agents to treat these disorders are laborious and observer dependent. Here, we describe a partially automated, high-throughput sickling assay using imaging flow cytometry.

Entities:  

Keywords:  Imaging flow cytometry; Sickle cell disease; Sickling assay

Mesh：

Substances：

Year:  2016        PMID： 27460253      PMCID： PMC5826554          DOI： 10.1007/978-1-4939-3302-0_20

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

Review 1.  Sickle cell biomechanics.

Authors:  Gilda A Barabino; Manu O Platt; Dhananjay K Kaul
Journal:  Annu Rev Biomed Eng       Date:  2010-08-15       Impact factor: 9.590

2.  Exposure of blood from patients with sickle cell disease to air changes the morphological, oxygen-binding, and sickling properties of sickled erythrocytes.

Authors:  Kazuo Obata; Julian Mattiello; Kenji Asakura; Kwaku Ohene-Frempong; Toshio Asakura
Journal:  Am J Hematol       Date:  2006-01       Impact factor: 10.047

3.  Morphologic studies of sickle erythrocytes by image analysis.

Authors:  K Horiuchi; J Ohata; Y Hirano; T Asakura
Journal:  J Lab Clin Med       Date:  1990-05

4.  Erythrocyte sickling during exercise and thermal stress.

Authors:  Michael F Bergeron; Joseph G Cannon; Elaina L Hall; Abdullah Kutlar
Journal:  Clin J Sport Med       Date:  2004-11       Impact factor: 3.638

5.  Imaging flow cytometry for automated detection of hypoxia-induced erythrocyte shape change in sickle cell disease.

Authors:  Eduard J van Beers; Leigh Samsel; Laurel Mendelsohn; Rehan Saiyed; Kleber Y Fertrin; Christine A Brantner; Mathew P Daniels; James Nichols; J Philip McCoy; Gregory J Kato
Journal:  Am J Hematol       Date:  2014-04-12       Impact factor: 10.047

6.  RATE OF SICKLING OF RED CELLS DURING DEOXYGENATION OF BLOOD FROM PERSONS WITH VARIOUS SICKLING DISORDERS.

Authors:  S CHARACHE; C L CONLEY
Journal:  Blood       Date:  1964-07       Impact factor: 22.113

7.  Hemoglobin S polymerization: primary determinant of the hemolytic and clinical severity of the sickling syndromes.

Authors:  G M Brittenham; A N Schechter; C T Noguchi
Journal:  Blood       Date:  1985-01       Impact factor: 22.113
  7 in total
  4 in total

1.  Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.

Authors:  Sriram Krishnamoorthy; Betty Pace; Dipti Gupta; Sarah Sturtevant; Biaoru Li; Levi Makala; Julia Brittain; Nancy Moore; Benjamin F Vieira; Timothy Thullen; Ivan Stone; Huo Li; William E Hobbs; David R Light
Journal:  JCI Insight       Date:  2017-10-19

2.  MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.

Authors:  Melanie Demers; Sarah Sturtevant; Kevin R Guertin; Dipti Gupta; Kunal Desai; Benjamin F Vieira; Wenjing Li; Alexandra Hicks; Ayman Ismail; Bronner P Gonçalves; Giuseppe Di Caprio; Ethan Schonbrun; Scott Hansen; Faik N Musayev; Martin K Safo; David K Wood; John M Higgins; David R Light
Journal:  Blood Adv       Date:  2021-03-09

3.  High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells.

Authors:  Akito Nakagawa; Marissa K Cooper; Maria Kost-Alimova; James Berstler; Binglan Yu; Lorenzo Berra; Elizabeth S Klings; Mary S Huang; Matthew M Heeney; Donald B Bloch; Warren M Zapol
Journal:  ACS Omega       Date:  2022-04-15

Review 4.  Techniques for the Detection of Sickle Cell Disease: A Review.

Authors:  Wjdan A Arishi; Hani A Alhadrami; Mohammed Zourob
Journal:  Micromachines (Basel)       Date:  2021-05-05       Impact factor: 2.891
  4 in total

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