H Kaya1, O Beton2, G Acar3, A Temizhan4, Y Cavusoğlu5, U Guray6, M Zoghi7, D Ural8, A Ekmekci9, H Gungor10, I Sari11, D Oguz12, H Yucel2, A Zorlu2, M B Yilmaz2. 1. Faculty of Medicine, Department of Cardiology, Cumhuriyet University, 58140, Sivas, Turkey. drhakkikaya84@gmail.com. 2. Faculty of Medicine, Department of Cardiology, Cumhuriyet University, 58140, Sivas, Turkey. 3. Faculty of Medicine, Department of Cardiology, Sutcu Imam University, Kahramanmaras, Turkey. 4. Cardiology Clinics, Yukses Ihtisas Training and Research Hospital, Ankara, Turkey. 5. Faculty of Medicine, Department of Cardiology, Osmangazi University, Eskisehir, Turkey. 6. Cardiology Clinics, Ankara Numune Training and Research Hospital, Ankara, Turkey. 7. Faculty of Medicine, Department of Cardiology, Ege University, Izmir, Turkey. 8. Faculty of Medicine, Department of Cardiology, Koc University, Istanbul, Turkey. 9. Cardiology Clinics, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. 10. Faculty of Medicine, Department of Cardiology, Adnan Menderes University, Aydın, Turkey. 11. Faculty of Medicine, Department of Cardiology, Marmara University, Istanbul, Turkey. 12. Faculty of Medicine, Department of Cardiology, Baskent University, Ankara, Turkey.
Abstract
BACKGROUND: The current study aimed to evaluate the influence of regular annual influenza vaccinations on cardiovascular (CV) death and heart failure-related hospitalizations (HFrH) in stable outpatients with heart failure with reduced ejection fraction. METHODS: The Turkish research team-HF (TREAT-HF) is a network undertaking multicenter, observational cohort studies in HF. This study is a subgroup analysis of TREAT-HF outpatient cohorts who completed a questionnaire on influenza vaccination status and for whom follow-up data were available. A total of 656 patients with available follow-up data for CV death and HFrH including recurrent hospitalization were included in the study. Patients were classified into two groups: those who received regular influenza vaccination (40 %) and those who did not receive vaccination. RESULTS: During a mean follow-up of 15 ±6 months, 113 (18 %) patients had CV death and 471 (72 %) patients had at least one HFrH. The CV death rate was similar in both groups of patients (16 vs. 19 %, p = 0.37), whereas, HFrH and recurrent HFrH were significantly less frequently encountered in patients who received regular influenza vaccination than in those who did not receive vaccination (43 vs. 92 % and 16 vs. 66 %, p < 0.001, respectively). In a multivariate Cox proportional hazards model - in addition to a few clinical factors - vaccination status (HR = 0.30, 95 % CI = 0.17-0.51, p < 0.001) and graduation from university (HR = 0.35, 95 % CI = 0.17-0.72, p = 0.004) remained independently associated with the risk of recurrent HFrH. CONCLUSION: Regular influenza vaccination does not influence CV deaths; however, it decreases HFrH including recurrent episodes of HFrH in outpatients with heart failure with reduced ejection fraction.
BACKGROUND: The current study aimed to evaluate the influence of regular annual influenza vaccinations on cardiovascular (CV) death and heart failure-related hospitalizations (HFrH) in stable outpatients with heart failure with reduced ejection fraction. METHODS: The Turkish research team-HF (TREAT-HF) is a network undertaking multicenter, observational cohort studies in HF. This study is a subgroup analysis of TREAT-HF outpatient cohorts who completed a questionnaire on influenza vaccination status and for whom follow-up data were available. A total of 656 patients with available follow-up data for CV death and HFrH including recurrent hospitalization were included in the study. Patients were classified into two groups: those who received regular influenza vaccination (40 %) and those who did not receive vaccination. RESULTS: During a mean follow-up of 15 ±6 months, 113 (18 %) patients had CV death and 471 (72 %) patients had at least one HFrH. The CV death rate was similar in both groups of patients (16 vs. 19 %, p = 0.37), whereas, HFrH and recurrent HFrH were significantly less frequently encountered in patients who received regular influenza vaccination than in those who did not receive vaccination (43 vs. 92 % and 16 vs. 66 %, p < 0.001, respectively). In a multivariate Cox proportional hazards model - in addition to a few clinical factors - vaccination status (HR = 0.30, 95 % CI = 0.17-0.51, p < 0.001) and graduation from university (HR = 0.35, 95 % CI = 0.17-0.72, p = 0.004) remained independently associated with the risk of recurrent HFrH. CONCLUSION: Regular influenza vaccination does not influence CV deaths; however, it decreases HFrH including recurrent episodes of HFrH in outpatients with heart failure with reduced ejection fraction.
Authors: Amy Van Ermen; Matthew P Hermanson; John M Moran; Nancy K Sweitzer; Maryl R Johnson; Orly Vardeny Journal: Eur J Heart Fail Date: 2013-01-04 Impact factor: 15.534
Authors: John J V McMurray; Stamatis Adamopoulos; Stefan D Anker; Angelo Auricchio; Michael Böhm; Kenneth Dickstein; Volkmar Falk; Gerasimos Filippatos; Cândida Fonseca; Miguel Angel Gomez-Sanchez; Tiny Jaarsma; Lars Køber; Gregory Y H Lip; Aldo Pietro Maggioni; Alexander Parkhomenko; Burkert M Pieske; Bogdan A Popescu; Per K Rønnevik; Frans H Rutten; Juerg Schwitter; Petar Seferovic; Janina Stepinska; Pedro T Trindade; Adriaan A Voors; Faiez Zannad; Andreas Zeiher Journal: Eur Heart J Date: 2012-05-19 Impact factor: 29.983
Authors: Muzaffer Değertekin; Cetin Erol; Oktay Ergene; Lale Tokgözoğlu; Mehmet Aksoy; Mustafa Kemal Erol; Mehmet Eren; Mahmut Sahin; Elif Eroğlu; Bülent Mutlu; Omer Kozan Journal: Turk Kardiyol Dern Ars Date: 2012-06
Authors: Jesús Álvarez-García; Andreu Ferrero-Gregori; Teresa Puig; Rafael Vázquez; Juan Delgado; Domingo Pascual-Figal; Luis Alonso-Pulpón; José R González-Juanatey; Miguel Rivera; Fernando Worner; Alfredo Bardají; Juan Cinca Journal: Eur J Heart Fail Date: 2015-05-23 Impact factor: 15.534
Authors: Matthew T Mefford; Ran Liu; Katia Bruxvoort; Lei Qian; Jonathan M Doris; Sandra Y Koyama; Hung Fu Tseng; Kristi Reynolds Journal: J Gen Intern Med Date: 2021-08-11 Impact factor: 6.473
Authors: Siva H Yedlapati; Safi U Khan; Swapna Talluri; Ahmed N Lone; Muhammad Zia Khan; Muhammad Shahzeb Khan; Ann M Navar; Martha Gulati; Heather Johnson; Seth Baum; Erin D Michos Journal: J Am Heart Assoc Date: 2021-03-13 Impact factor: 5.501
Authors: Sanjay Poudel; Fadi Shehadeh; Ioannis M Zacharioudakis; Giannoula S Tansarli; Fainareti N Zervou; Markos Kalligeros; Robertus van Aalst; Ayman Chit; Eleftherios Mylonakis Journal: Open Forum Infect Dis Date: 2019-04-02 Impact factor: 3.835