Heeyoon Cho1,2, Yong Un Shin2, Nicole H Siegel3, Hyeong Gon Yu4, Lucia Sobrin1, Achal Patel3, Marlene L Durand1,5, Joan W Miller1, Deeba Husain1. 1. a Department of Ophthalmology, Massachusetts Eye and Ear Infirmary , Harvard Medical School , Boston , Massachusetts , USA. 2. b Department of Ophthalmology , Hanyang University Medical College , Seoul , Republic of Korea. 3. c Department of Ophthalmology , Boston University School of Medicine , Boston , Massachusetts , USA. 4. d Department of Ophthalmology , Seoul National University College of Medicine , Seoul , Republic of Korea. 5. e Infectious Disease Unit, Department of Medicine , Massachusetts General Hospital, Harvard Medical School , Boston , Massachusetts , USA.
Abstract
PURPOSE: To study the clinical features of endogenous endophthalmitis (EE) in sample patient populations from the USA and South Korea over an 8-year period. METHODS: We reviewed data from 128 eyes of 60 American and 48 Korean patients diagnosed with EE and compared their clinical characteristics. RESULTS: Fungemia and liver abscess were the most common extraocular infection sources among American (26.7%) and Korean patients (33.3%), respectively. Klebsiella pneumoniae and Candida species were the most common pathogens of EE in the Korean and the American patients, respectively. Endophthalmitis caused by fungi had a better visual prognosis than that caused by bacteria (p = 0.001). Vitrectomy was beneficial for eyes with EE due to virulent bacteria presenting with worse than counting finger vision. CONCLUSIONS: The predisposing conditions and responsible organisms for EE vary in different regions of the world. The visual prognosis was strongly influenced by the underlying pathogen.
PURPOSE: To study the clinical features of endogenous endophthalmitis (EE) in sample patient populations from the USA and South Korea over an 8-year period. METHODS: We reviewed data from 128 eyes of 60 American and 48 Korean patients diagnosed with EE and compared their clinical characteristics. RESULTS:Fungemia and liver abscess were the most common extraocular infection sources among American (26.7%) and Korean patients (33.3%), respectively. Klebsiella pneumoniae and Candida species were the most common pathogens of EE in the Korean and the American patients, respectively. Endophthalmitis caused by fungi had a better visual prognosis than that caused by bacteria (p = 0.001). Vitrectomy was beneficial for eyes with EE due to virulent bacteria presenting with worse than counting finger vision. CONCLUSIONS: The predisposing conditions and responsible organisms for EE vary in different regions of the world. The visual prognosis was strongly influenced by the underlying pathogen.
Authors: Ji Hwan Lee; Hee Suk Kim; Suk Ho Byeon; Sung Soo Kim; Hyoung Jun Koh; Sung Chul Lee; Christopher Seungkyu Lee Journal: Int Ophthalmol Date: 2022-04-17 Impact factor: 2.029