| Literature DB >> 27459336 |
Z Wu1,2, G Wang3, D Pan1,2, Y Guo1, X Zeng2, Y Sun2, J Cao2.
Abstract
Exopolysaccharides (EPS) have attracted attention recently for possible use in suppressing early stage breast cancer. In this study, a mannan EPS produced by Lactococcus lactis subsp. lactis was found to affect the production of inflammatory cytokines. EPS (300 μg/ml) can significantly enhance tumour necrosis factor alpha and inducible NO synthase release in MCF-7 cells compared to control cells in a concentration-dependent manner. Also the intracellular calcium level was found to increase with the concentration of EPS. After EPS-treatment, a significant reduction in mitochondrial potential was observed, as was nuclear condensation and cell shrinkage. These results may be helpful in further understanding the anti-tumour properties of lactic acid bacteria.Entities:
Keywords: MCF-7 cells; anti-tumour effects; apoptosis; caspases; exopolysaccharides
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Year: 2016 PMID： 27459336 DOI： 10.3920/BM2015.0192
Source DB: PubMed Journal: Benef Microbes ISSN： 1876-2883 Impact factor: 4.205