Samar Hafida1, Tooraj Mirshahi, Barbara S Nikolajczyk. 1. aSection of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts bWeis Center for Research; Geisinger Obesity Institute, Geisinger Clinic, Danville, Pennsylvania cDepartment of Microbiology; Department of Pathology; Department of Medicine; Department of Molecular and Cell Biology, Boston University School of Medicine, Boston, Massachusetts, USA.
Abstract
PURPOSE OF REVIEW: Numerous lines of evidence support the likelihood that inflammation drives the transition from obese/metabolically healthy to obese/type 2 diabetes (T2D). Given the temporal flexibility of inflammation in obesity-associated T2D, investigators have hypothesized that a precipitous drop in diabetogenic cytokines is critical for rapid 'T2D remission' following surgery but prior to significant weight loss. We review the evidence that changes in diabetogenic cytokines play a role in outcomes of bariatric surgery, including improved glycemic control. RECENT FINDINGS: A 2016 indication for bariatric surgery to treat T2D integrates the large body of data showing rapid metabolic improvement. Parameters that account for improved glycemic control prior to significant weight loss, T2D recidivism over the long term, or failure of surgery to remit T2D in some patients are incompletely understood. SUMMARY: We review the evidence that changes in diabetogenic cytokines play a role in outcomes of bariatric surgery, including improved glycemic control. We brainstorm future research directions that may improve surgical results.
PURPOSE OF REVIEW: Numerous lines of evidence support the likelihood that inflammation drives the transition from obese/metabolically healthy to obese/type 2 diabetes (T2D). Given the temporal flexibility of inflammation in obesity-associated T2D, investigators have hypothesized that a precipitous drop in diabetogenic cytokines is critical for rapid 'T2D remission' following surgery but prior to significant weight loss. We review the evidence that changes in diabetogenic cytokines play a role in outcomes of bariatric surgery, including improved glycemic control. RECENT FINDINGS: A 2016 indication for bariatric surgery to treat T2D integrates the large body of data showing rapid metabolic improvement. Parameters that account for improved glycemic control prior to significant weight loss, T2D recidivism over the long term, or failure of surgery to remit T2D in some patients are incompletely understood. SUMMARY: We review the evidence that changes in diabetogenic cytokines play a role in outcomes of bariatric surgery, including improved glycemic control. We brainstorm future research directions that may improve surgical results.
Authors: N B Jørgensen; S H Jacobsen; C Dirksen; K N Bojsen-Møller; L Naver; L Hvolris; T R Clausen; B S Wulff; D Worm; D Lindqvist Hansen; S Madsbad; J J Holst Journal: Am J Physiol Endocrinol Metab Date: 2012-04-24 Impact factor: 4.310
Authors: Andrew L Carey; Gregory R Steinberg; S Lance Macaulay; Walter G Thomas; Anna G Holmes; Georg Ramm; Oja Prelovsek; Cordula Hohnen-Behrens; Matthew J Watt; David E James; Bruce E Kemp; Bente K Pedersen; Mark A Febbraio Journal: Diabetes Date: 2006-10 Impact factor: 9.461
Authors: Hakeam A Hakeam; Patrick J O'Regan; Abdulrahman M Salem; Fahad Y Bamehriz; Lina F Jomaa Journal: Obes Surg Date: 2008-10-08 Impact factor: 4.129
Authors: Nicola Veronese; Cyrus Cooper; Jean-Yves Reginster; Marc Hochberg; Jaime Branco; Olivier Bruyère; Roland Chapurlat; Nasser Al-Daghri; Elaine Dennison; Gabriel Herrero-Beaumont; Jean-François Kaux; Emmanuel Maheu; René Rizzoli; Roland Roth; Lucio C Rovati; Daniel Uebelhart; Mila Vlaskovska; André Scheen Journal: Semin Arthritis Rheum Date: 2019-01-11 Impact factor: 5.532
Authors: Sofia Castro Oliveira; J S Neves; P Souteiro; J Pedro; D Magalhães; V Guerreiro; R Bettencourt-Silva; M M Costa; A Varela; I Barroso; P Freitas; D Carvalho Journal: Obes Surg Date: 2020-02 Impact factor: 4.129
Authors: Peter N Benotti; G Craig Wood; David J Carey; Vishal C Mehra; Tooraj Mirshahi; Michelle R Lent; Anthony T Petrick; Christopher Still; Glenn S Gerhard; Annemarie G Hirsch Journal: J Am Heart Assoc Date: 2017-05-23 Impact factor: 5.501
Authors: Grace McCambridge; Madhur Agrawal; Alanna Keady; Philip A Kern; Hatice Hasturk; Barbara S Nikolajczyk; Leena P Bharath Journal: Biomolecules Date: 2019-02-25
Authors: Paweł A Wojciak; Patrycja Pawłuszewicz; Inna Diemieszczyk; Ewa Komorowska-Wojtunik; Mikołaj Czerniawski; Adam Krętowski; Agnieszka Błachnio-Zabielska; Jacek Dadan; Jerzy R Ładny; Hady Razak Hady Journal: Wideochir Inne Tech Maloinwazyjne Date: 2019-04-25 Impact factor: 1.195