Veeravich Jaruvongvanich1,2, Anawin Sanguankeo3,4, Karn Wijarnpreecha4, Sikarin Upala3,4. 1. Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. 2. Department of Internal Medicine, University of Hawaii, Honolulu, USA. 3. Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. 4. Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, USA.
Abstract
BACKGROUND AND AIM: Diverticular disease and colorectal neoplasia are common digestive disorders worldwide. Both diseases share epidemiological trends and certain risk factors including advancing age, physical inactivity, and Western diet and lifestyle. Studies assessing the association between these diseases reported inconsistent results. Thus, we conducted a systematic review and meta-analysis to determine the association between diverticular disease and colorectal adenomas, advanced adenomas and cancer. METHODS: A comprehensive search of the databases MEDLINE and EMBASE was done from inception through March 2016. Inclusion criterion was the observational studies' assessment of the association between diverticular disease and colorectal neoplasia in adult participants. Pooled OR and 95% confidence interval (CI) were calculated using a random effect. RESULTS: Data were extracted from 14 observational studies (11 cross-sectional studies, one case-control study and two cohort studies). Diverticular disease was associated with increased odds of adenomas (OR = 1.67, 95% CI 1.27-2.21, 10 studies), but not associated with advanced adenomas (OR = 1.19, 95% CI 0.88-1.62, I2 = 52%, four studies) or colorectal cancer (OR = 1.36, 95% CI 0.47-3.92, I2 = 98%, seven studies). CONCLUSIONS: Our meta-analysis demonstrated that diverticular disease was associated with colorectal adenomas. Colonoscopists should be aware of this association and carefully examine the entire large bowel in individuals with diverticulosis.
BACKGROUND AND AIM: Diverticular disease and colorectal neoplasia are common digestive disorders worldwide. Both diseases share epidemiological trends and certain risk factors including advancing age, physical inactivity, and Western diet and lifestyle. Studies assessing the association between these diseases reported inconsistent results. Thus, we conducted a systematic review and meta-analysis to determine the association between diverticular disease and colorectal adenomas, advanced adenomas and cancer. METHODS: A comprehensive search of the databases MEDLINE and EMBASE was done from inception through March 2016. Inclusion criterion was the observational studies' assessment of the association between diverticular disease and colorectal neoplasia in adult participants. Pooled OR and 95% confidence interval (CI) were calculated using a random effect. RESULTS: Data were extracted from 14 observational studies (11 cross-sectional studies, one case-control study and two cohort studies). Diverticular disease was associated with increased odds of adenomas (OR = 1.67, 95% CI 1.27-2.21, 10 studies), but not associated with advanced adenomas (OR = 1.19, 95% CI 0.88-1.62, I2 = 52%, four studies) or colorectal cancer (OR = 1.36, 95% CI 0.47-3.92, I2 = 98%, seven studies). CONCLUSIONS: Our meta-analysis demonstrated that diverticular disease was associated with colorectal adenomas. Colonoscopists should be aware of this association and carefully examine the entire large bowel in individuals with diverticulosis.
Authors: Fadi Abu Baker; Jesus Alonso Z'cruz De La Garza; Amir Mari; Abdel-Rauf Zeina; Amani Bishara; Oren Gal; Yael Kopelman Journal: Gastroenterol Res Pract Date: 2019-12-01 Impact factor: 2.260
Authors: Xiaomeng Zhang; Xue Li; Yazhou He; Philip J Law; Susan M Farrington; Harry Campbell; Ian P M Tomlinson; Richard S Houlston; Malcolm G Dunlop; Maria Timofeeva; Evropi Theodoratou Journal: Br J Cancer Date: 2021-12-15 Impact factor: 7.640