Literature DB >> 27453707

High-Throughput Microfluidic Device for Circulating Tumor Cell Isolation from Whole Blood.

Daniel K Yang1, Serena Leong2, Lydia L Sohn1.   

Abstract

Circulating tumor cells (CTCs) are promising markers to determine cancer patient prognosis and track disease response to therapy. We present a multi-stage microfluidic device we have developed that utilizes inertial and Dean drag forces for isolating CTCs from whole blood. We demonstrate a 94.2% ± 2.1% recovery of cancer cells with our device when screening whole blood spiked with MCF-7 GFP cells.

Entities:  

Keywords:  CTC; Inertial microfluidics; Size-based separation

Year:  2015        PMID： 27453707      PMCID： PMC4956345     

Source DB:  PubMed          Journal:  Micro Total Anal Syst        ISSN： 1556-5890


  9 in total

1.  Label-free cancer cell separation from human whole blood using inertial microfluidics at low shear stress.

Authors:  Myung Gwon Lee; Joong Ho Shin; Chae Yun Bae; Sungyoung Choi; Je-Kyun Park
Journal:  Anal Chem       Date:  2013-06-13       Impact factor: 6.986

2.  Highly efficient assay of circulating tumor cells by selective sedimentation with a density gradient medium and microfiltration from whole blood.

Authors:  Jong-Myeon Park; June-Young Lee; Jeong-Gun Lee; Hyoyoung Jeong; Jin-Mi Oh; Yeon Jeong Kim; Donghyun Park; Minseok S Kim; Hun Joo Lee; Jin Ho Oh; Soo Suk Lee; Won-Yong Lee; Nam Huh
Journal:  Anal Chem       Date:  2012-08-23       Impact factor: 6.986

Review 3.  Microfluidic: an innovative tool for efficient cell sorting.

Authors:  Julien Autebert; Benoit Coudert; François-Clément Bidard; Jean-Yves Pierga; Stéphanie Descroix; Laurent Malaquin; Jean-Louis Viovy
Journal:  Methods       Date:  2012-07-11       Impact factor: 3.608

4.  Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells.

Authors:  G Vona; A Sabile; M Louha; V Sitruk; S Romana; K Schütze; F Capron; D Franco; M Pazzagli; M Vekemans; B Lacour; C Bréchot; P Paterlini-Bréchot
Journal:  Am J Pathol       Date:  2000-01       Impact factor: 4.307

Review 5.  Inertial microfluidic physics.

Authors:  Hamed Amini; Wonhee Lee; Dino Di Carlo
Journal:  Lab Chip       Date:  2014-06-10       Impact factor: 6.799

Review 6.  Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications.

Authors:  Ramdane Harouaka; Zhigang Kang; Si-Yang Zheng; Liang Cao
Journal:  Pharmacol Ther       Date:  2013-10-14       Impact factor: 12.310

Review 7.  Circulating tumor cells: approaches to isolation and characterization.

Authors:  Min Yu; Shannon Stott; Mehmet Toner; Shyamala Maheswaran; Daniel A Haber
Journal:  J Cell Biol       Date:  2011-02-07       Impact factor: 10.539

8.  Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient.

Authors:  Kevin G Phillips; Carmen Ruiz Velasco; Julia Li; Anand Kolatkar; Madelyn Luttgen; Kelly Bethel; Bridgette Duggan; Peter Kuhn; Owen J T McCarty
Journal:  Front Oncol       Date:  2012-07-18       Impact factor: 6.244

Review 9.  Detecting circulating tumor cells: current challenges and new trends.

Authors:  Bin Hong; Youli Zu
Journal:  Theranostics       Date:  2013-04-23       Impact factor: 11.556
  9 in total
  1 in total

1.  Current Trends in Microfluidics and Biosensors for Cancer Research Applications.

Authors:  David Caballero; Rui L Reis; Subhas C Kundu
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650
  1 in total

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