Joe M El-Khoury1, Dustin R Bunch2, Bo Hu3, Drew Payto2, Edmunds Z Reineks2, Sihe Wang4. 1. Department of Laboratory Medicine, Yale University, New Haven, CT 06510, United States. 2. Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44195, United States. 3. Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, United States. 4. Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44195, United States. Electronic address: wangs2@ccf.org.
Abstract
OBJECTIVES: Symmetric dimethylarginine (SDMA) is a catabolic product of arginine-methylated proteins and is an emerging biomarker for kidney function. A limited number of studies in selected populations have shown good correlation between SDMA and a few known markers of glomerular filtration rate (GFR). However, a comprehensive comparison of SDMA with all existing serum endogenous markers in a population with varied kidney function and against measured GFR is lacking. The objective of this study was to compare the correlations of SDMA, creatinine, cystatin C and their eGFR equations against GFR measured by iothalamate clearance in an adult population with varied kidney function. DESIGN & METHODS: Left-over serum and plasma specimens were collected from 40 adults with normal and reduced kidney function. GFR was measured using a radioactive iothalamate procedure. Creatinine and cystatin C were measured on Roche Cobas 8000. SDMA was measured by a published liquid chromatography-tandem mass spectrometry method. RESULTS: SDMA correlated highly with measured GFR (r=-0.84), which was better than creatinine (r=-0.70) but equivalent to cystatin C (r=-0.86) and the eGFR equations [MDRD and CKD-EPI (separate and combined)]. CONCLUSIONS: SDMA is a strong marker of kidney function and further studies are needed to establish an eGFR formula that includes it for widespread clinical use.
OBJECTIVES: Symmetric dimethylarginine (SDMA) is a catabolic product of arginine-methylated proteins and is an emerging biomarker for kidney function. A limited number of studies in selected populations have shown good correlation between SDMA and a few known markers of glomerular filtration rate (GFR). However, a comprehensive comparison of SDMA with all existing serum endogenous markers in a population with varied kidney function and against measured GFR is lacking. The objective of this study was to compare the correlations of SDMA, creatinine, cystatin C and their eGFR equations against GFR measured by iothalamate clearance in an adult population with varied kidney function. DESIGN & METHODS: Left-over serum and plasma specimens were collected from 40 adults with normal and reduced kidney function. GFR was measured using a radioactive iothalamate procedure. Creatinine and cystatin C were measured on Roche Cobas 8000. SDMA was measured by a published liquid chromatography-tandem mass spectrometry method. RESULTS:SDMA correlated highly with measured GFR (r=-0.84), which was better than creatinine (r=-0.70) but equivalent to cystatin C (r=-0.86) and the eGFR equations [MDRD and CKD-EPI (separate and combined)]. CONCLUSIONS:SDMA is a strong marker of kidney function and further studies are needed to establish an eGFR formula that includes it for widespread clinical use.
Authors: Charles T Quinn; Santosh L Saraf; Victor R Gordeuk; Courtney D Fitzhugh; Susan E Creary; Prasad Bodas; Alex George; Ashok B Raj; Alecia C Nero; Catherine E Terrell; Lisa McCord; Adam Lane; Hans C Ackerman; Yu Yang; Omar Niss; Michael D Taylor; Prasad Devarajan; Punam Malik Journal: Am J Hematol Date: 2017-07-19 Impact factor: 10.047
Authors: Diane M Hamlin; A Eric Schultze; Michael J Coyne; Donald J McCrann; Rebekah Mack; Corie Drake; Rachel E Murphy; Julie Cross; Marilyn Strong-Townsend; Maha Yerramilli; Mary K Leissinger Journal: Kidney360 Date: 2021-12-07
Authors: Ellen R Brooks; Shannon Haymond; Alfred Rademaker; Christopher Pierce; Irene Helenowski; Rod Passman; Faye Vicente; Bradley A Warady; Susan L Furth; Craig B Langman Journal: Pediatr Nephrol Date: 2017-12-07 Impact factor: 3.714
Authors: André Nanny Vieira Le Sueur; Silvano Salgueiro Geraldes; Alessandra Melchert; Regina Kiomi Takahira; Michael Coyne; Rachel Murphy; Donald Szlosek; Priscylla Tatiana Chalfun Guimarães-Okamoto Journal: J Vet Intern Med Date: 2019-09-12 Impact factor: 3.333
Authors: Ahmed Alaini; Deepak Malhotra; Helbert Rondon-Berrios; Christos P Argyropoulos; Zeid J Khitan; Dominic S C Raj; Mark Rohrscheib; Joseph I Shapiro; Antonios H Tzamaloukas Journal: World J Methodol Date: 2017-09-26
Authors: Edzard Schwedhelm; Jelena Kornej; Petra Büttner; Martin Bahls; Rainer H Böger; Gerhard Hindricks; Holger Thiele Journal: J Mol Med (Berl) Date: 2020-06-06 Impact factor: 4.599
Authors: Verena Lehmann; Barblin Altherr; Nikola Pantchev; Sabine Öfner; Yury Zablotski; Rachel Murphy; Michael Coyne; Petra Kölle Journal: Front Vet Sci Date: 2022-02-22