Literature DB >> 27452145

Metabolic Precision Medicines: Curing POMC Deficiency.

Timo D Müller1, Matthias H Tschöp2, Stephen O'Rahilly3.   

Abstract

Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27452145     DOI： 10.1016/j.cmet.2016.07.006

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  4 in total

Review 1.  The melanocortin pathway and control of appetite-progress and therapeutic implications.

Authors:  Giulia Baldini; Kevin D Phelan
Journal:  J Endocrinol       Date:  2019-04-01       Impact factor: 4.286

Review 2.  Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R).

Authors:  V Hainer; I Aldhoon Hainerová; M Kunešová; R Taxová Braunerová; H Zamrazilová; B Bendlová
Journal:  Physiol Res       Date:  2020-09-30       Impact factor: 1.881

3.  Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.

Authors:  Nitin Agarwal; Thomas Fleming; Divija Deshpande; Claire Gaveriaux-Ruff; Christoph S N Klose; Anke Tappe-Theodor; Rohini Kuner; Peter Nawroth
Journal:  Nat Commun       Date:  2021-01-18       Impact factor: 14.919

4.  Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.

Authors:  Kristin L Ayers; Benjamin S Glicksberg; Alastair S Garfield; Simonne Longerich; Joseph A White; Pengwei Yang; Lei Du; Thomas W Chittenden; Jeffery R Gulcher; Sophie Roy; Fred Fiedorek; Keith Gottesdiener; Sarah Cohen; Kari E North; Eric E Schadt; Shuyu D Li; Rong Chen; Lex H T Van der Ploeg
Journal:  J Clin Endocrinol Metab       Date:  2018-07-01       Impact factor: 5.958
  4 in total

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