G Andrikopoulos1, D Terentes-Printzios2, S Tzeis3, C Vlachopoulos2, C Varounis4, N Nikas5, J Lekakis4, D Stakos6, S Lymperi7, D Symeonidis8, D Chrissos9, C Kyrpizidis10, D Alexopoulos11, S Zombolos12, S Foussas13, Α Κranidis14, Κ Oikonomou15, V Vasilikos16, P Andronikos17, Α Dermitzakis18, D Richter19, N Fragakis20, I Styliadis21, S Mavridis22, C Stefanadis2, P Vardas23. 1. Henry Dunant Hospital Center, Athens, Greece. Electronic address: andrikop@hotmail.com. 2. 1st Cardiology Department, Hippokration Hospital, University of Athens Medical School, Greece. 3. Henry Dunant Hospital Center, Athens, Greece. 4. University of Athens Medical School, Attikon University Hospital, Athens, Greece. 5. AstraZeneca SA, Medical Department, Athens, Greece. 6. Cardiology Clinic, Democritus University of Thrace, Alexandroupolis, Greece. 7. Cardiology Department, Sotiria Chest Diseases Hospital, Athens, Greece. 8. Cardiology Department, General Hospital of Kavala, Kavala, Greece. 9. Cardiology Department, Tripoli General Hospital, Tripoli, Greece. 10. Department of Cardiology, 2nd IKA Hospital, Thessaloniki, Greece. 11. Department of Cardiology, Patras University Hospital, Patras, Greece. 12. Department of Cardiology, General Hospital of Messinia, Kalamata, Greece. 13. Cardiology Department, Tzaneio State Hospital, Piraeus, Greece. 14. Cardiology Department, Western Attica General Hospital of Athens, Greece. 15. Cardiology Department, General Hospital of Edessa, Edessa, Greece. 16. First Department of Cardiology, AHEPA University Hospital, Aristotle University Medical School, Thessaloniki, Greece; Third Department of Cardiology, Hippokration University Hospital, Aristotle University Medical School, Thessaloniki, Greece. 17. Department of Cardiology, Vostanion Hospital, Mytilini, Greece. 18. Department of Cardiology, Venizelio General Hospital, Crete, Greece. 19. Second Department of Cardiology, Athens Euroclinic, Greece. 20. Third Cardiology Department, Hippokration Hospital, Aristotle University Medical School, Thessaloniki, Greece. 21. Department of Cardiology, General Hospital of Aigio, Aigio, Greece. 22. Department of Cardiology, General Hospital of Sparti, Lakonia, Sparti, Greece. 23. Department of Cardiology, Heraklion University Hospital, Crete, Greece.
Abstract
INTRODUCTION: In view of recent therapeutic breakthroughs in acute coronary syndromes (ACS) and essential demographic and socioeconomic changes in Greece, we conducted the prospective, multi-center, nationwide PHAETHON study (An Epidemiological Cohort Study of Acute Coronary Syndromes in the Greek Population) that aimed to recruit a representative cohort of ACS patients and examine current management practices and patient prognosis. METHODS: The PHAETHON study was conducted from May 2012 to February 2014. We enrolled 800 consecutive ACS patients from 37 hospitals with a proportional representation of all types of hospitals and geographical areas. Patients were followed for a median period of 189 days. Outcome was assessed with a composite endpoint of death, myocardial infarction, stroke, urgent revascularization and urgent hospitalization for cardiovascular causes. RESULTS: The mean age of patients was 62.7 years (78% males). The majority of patients (n=411, 51%) presented with ST-elevation myocardial infarction (STEMI), whereas 389 patients presented with NSTEMI (n=303, 38%) or UA (n=86, 11%). Overall, 58.8% of the patients had hypertension, 26.5% were diabetic, 52.5% had dyslipidemia, 71.1% had a smoking history (current or past), 25.8% had a family history of coronary artery disease (CAD) and 24.1% had a prior history of CAD. In STEMI patients, 44.5% of patients were treated with thrombolysis, 38.9% underwent a coronary angiogram (34.1% were treated with primary percutaneous coronary intervention) and 16.5% did not receive urgent treatment. The pain-to-door time was 169 minutes. During hospitalization, 301 (38%) patients presented one or more complications, and 13 died (1.6%). During follow-up, 99 (12.6%) patients experienced the composite endpoint, and 21 died (2.7%). CONCLUSIONS: The PHAETHON study provided valuable insights into the epidemiology, management and outcome of ACS patients in Greece. Management of ACS resembles the management observed in other European countries. However, several issues still to be addressed by public authorities for the timely and proper management of ACS.
INTRODUCTION: In view of recent therapeutic breakthroughs in acute coronary syndromes (ACS) and essential demographic and socioeconomic changes in Greece, we conducted the prospective, multi-center, nationwide PHAETHON study (An Epidemiological Cohort Study of Acute Coronary Syndromes in the Greek Population) that aimed to recruit a representative cohort of ACS patients and examine current management practices and patient prognosis. METHODS: The PHAETHON study was conducted from May 2012 to February 2014. We enrolled 800 consecutive ACS patients from 37 hospitals with a proportional representation of all types of hospitals and geographical areas. Patients were followed for a median period of 189 days. Outcome was assessed with a composite endpoint of death, myocardial infarction, stroke, urgent revascularization and urgent hospitalization for cardiovascular causes. RESULTS: The mean age of patients was 62.7 years (78% males). The majority of patients (n=411, 51%) presented with ST-elevation myocardial infarction (STEMI), whereas 389 patients presented with NSTEMI (n=303, 38%) or UA (n=86, 11%). Overall, 58.8% of the patients had hypertension, 26.5% were diabetic, 52.5% had dyslipidemia, 71.1% had a smoking history (current or past), 25.8% had a family history of coronary artery disease (CAD) and 24.1% had a prior history of CAD. In STEMI patients, 44.5% of patients were treated with thrombolysis, 38.9% underwent a coronary angiogram (34.1% were treated with primary percutaneous coronary intervention) and 16.5% did not receive urgent treatment. The pain-to-door time was 169 minutes. During hospitalization, 301 (38%) patients presented one or more complications, and 13 died (1.6%). During follow-up, 99 (12.6%) patients experienced the composite endpoint, and 21 died (2.7%). CONCLUSIONS: The PHAETHON study provided valuable insights into the epidemiology, management and outcome of ACS patients in Greece. Management of ACS resembles the management observed in other European countries. However, several issues still to be addressed by public authorities for the timely and proper management of ACS.
Authors: Fatina B Ramadhani; Yilan Liu; Xue Jing; Ye Qing; Han Xiong; Fengjian Zhang; Pian Wei Journal: Afr Health Sci Date: 2020-12 Impact factor: 0.927