Literature DB >> 27451357

Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin.

Jing Liu1, Shuli Man2, Jing Li3, Yang Zhang3, Xin Meng3, Wenyuan Gao4.   

Abstract

Rhizoma Paridis saponin (RPS) had been regarded as the main active components responsible for the anti-tumor effects of the herb Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. In the present research, we set up a rat model of diethylnitrosamine (DEN) induced hepatoma to evaluate antitumor effect of RPS. After 20 weeks treatment, rats were sacrificed to perform histopathological examinations, liver function tests, oxidative stress assays and so forth. As a result, DEN-induced hepatoma formation. RPS alleviated levels of liver injury through inhibiting liver tissues of malondialdehyde (MDA) and nitric oxide (NO) formation, increasing superoxide dismutases (SOD) production, and up-regulating expression of GST-α/μ/π in DEN-induced rats. All in all, RPS would be a potent agent inhibiting chemically induced liver cancer in the prospective application.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Diethylnitrosamine; Hpatoma; Oxidative stress; Rhizoma paridis saponin

Mesh：

Substances：

Year:  2016        PMID： 27451357     DOI： 10.1016/j.etap.2016.07.004

Source DB:  PubMed          Journal:  Environ Toxicol Pharmacol        ISSN： 1382-6689            Impact factor:   4.860


  9 in total

1.  Hepatocellular Toxicity of Paris Saponins I, II, VI and VII on Two Kinds of Hepatocytes-HL-7702 and HepaRG Cells, and the Underlying Mechanisms.

Authors:  Wenping Wang; Yi Liu; Mingyi Sun; Na Sai; Longtai You; Xiaoxv Dong; Xingbin Yin; Jian Ni
Journal:  Cells       Date:  2019-07-09       Impact factor: 6.600

2.  Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway.

Authors:  Dejiang Pang; Chengcheng Yang; Chao Li; Yuanfeng Zou; Bin Feng; Lixia Li; Wentao Liu; Qihui Luo; Zhengli Chen; Chao Huang
Journal:  Biol Open       Date:  2020-02-07       Impact factor: 2.422

3.  The complete chloroplast genome of Paris polyphylla var. chinensis, an endemic medicinal herb in China.

Authors:  Xujun Wang; Cuiying Peng; Junsheng Liang; Qidong Liang; Caili Xu; Wei Guo
Journal:  Mitochondrial DNA B Resour       Date:  2019-11-08       Impact factor: 0.658

4.  Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats.

Authors:  Mariama Salihu; Gaber El-Saber Batiha; Keneth Iceland Kasozi; George D Zouganelis; Souty M Z Sharkawi; Eman Ibrahim Ahmed; Ibe Michael Usman; Halima Nalugo; Juma J Ochieng; Ibrahim Ssengendo; Olatayo Segun Okeniran; Theophilus Pius; Kyobe Ronald Kimanje; Eric Simidi Kegoye; Ritah Kenganzi; Fred Ssempijja
Journal:  Toxicol Rep       Date:  2022-03-29

5.  Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway.

Authors:  Yuhan Jiao; Ming Xin; Juanjuan Xu; Xindong Xiang; Xuan Li; Jingjing Jiang; Xiuqin Jia
Journal:  Pharm Biol       Date:  2022-12       Impact factor: 3.889

6.  Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression.

Authors:  Yanxia Guo; Zhiyong Liu; Kailin Li; Guangshang Cao; Chao Sun; Guanghui Cheng; Denglu Zhang; Wei Peng; Jiaxin Liu; Yuanfu Qi; Lu Zhang; Peng Wang; Yuan Chen; Zhaomin Lin; Yong Guan; Jianye Zhang; Jiliang Wen; Fang Wang; Feng Kong; Dawei Xu; Shengtian Zhao
Journal:  Curr Urol       Date:  2018-02-20

7.  Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats.

Authors:  Charatda Punvittayagul; Arpamas Chariyakornkul; Kanokwan Jarukamjorn; Rawiwan Wongpoomchai
Journal:  Molecules       Date:  2021-05-05       Impact factor: 4.411

8.  Design and Optimization of Orally Administered Luteolin Nanoethosomes to Enhance Its Anti-Tumor Activity against Hepatocellular Carcinoma.

Authors:  Mahmoud M A Elsayed; Tarek M Okda; Gamal M K Atwa; Gamal A Omran; Atef E Abd Elbaky; Abd El Hakim Ramadan
Journal:  Pharmaceutics       Date:  2021-05-02       Impact factor: 6.321

9.  Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.

Authors:  Jun Han; Jie Kan; Xinguo Wang; Qingling Yuan; Xiaoyan Song; Min Huang; Hao Wu
Journal:  Transl Cancer Res       Date:  2020-08       Impact factor: 1.241
  9 in total

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