Literature DB >> 27450033

Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders.

Eunee Lee1, Jiseok Lee2, Eunjoon Kim3.   

Abstract

Imbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target.
Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Autism spectrum disorders; Circuit; Excitation/inhibition balance; Mouse models; Psychiatric disorders; Synapse

Mesh：

Year:  2016        PMID： 27450033     DOI： 10.1016/j.biopsych.2016.05.011

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  139 in total

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