| Literature DB >> 27449787 |
Talitha I Verhoef1, Verena Trend2, Barry Kelly2,3, Nigel Robinson2, Paul Fox2, Stephen Morris4.
Abstract
BACKGROUND: We evaluated the cost-effectiveness of the Give-it-a-Go programme, which offers free leisure centre memberships to physically inactive members of the public in a single London Borough receiving state benefits.Entities:
Keywords: Cost-utility analysis; Health economics; Mental wellbeing; Physical activity
Mesh:
Year: 2016 PMID: 27449787 PMCID: PMC4957286 DOI: 10.1186/s12889-016-3300-x
Source DB: PubMed Journal: BMC Public Health ISSN: 1471-2458 Impact factor: 3.295
Fig. 1Markov model
General input parameters
| Base case value | Lower limit | Upper limit | Distribution for PSA | Source | |
|---|---|---|---|---|---|
| Starting age | 45 | 25 | 65 | Normal | GIAG |
| Proportion of recruited participants completing the programme | 15.5 % | 1 % | 50 % | Beta | GIAG |
| Baseline activity level-all recruited participants | |||||
| Low | 32.4 % | – | – | Dirichlet | GIAG |
| Moderate | 37.6 % | 25 % | 50 % | Dirichlet | GIAG |
| High | 30.0 % | 15 % | 50 % | Dirichlet | GIAG |
| Follow-up activity level-completers | |||||
| Low | 23.5 % | – | – | Dirichlet | GIAG |
| Moderate | 23.5 % | 10 % | 40 % | Dirichlet | GIAG |
| High | 52.9 % | 35 % | 65 % | Dirichlet | GIAG |
| Duration of effect of Give it a Go on PA (months) | 12 | 4 | 20 | Uniform | Assumption |
| Relative risks of coronary heart disease | |||||
| Moderate activity level | 0.90 | 0.83 | 0.99 | Lognormal | [ |
| High activity level | 0.81 | 0.68 | 0.96 | Lognormal | [ |
| Relative risks of stroke | |||||
| Moderate activity level | 0.86 | 0.79 | 0.93 | Lognormal | [ |
| High activity level | 0.74 | 0.64 | 0.85 | Lognormal | [ |
| Relative risks of type II diabetes | |||||
| Moderate activity level | 0.67 | 0.53 | 0.84 | Lognormal | [ |
| High activity level | 0.61 | 0.41 | 0.9 | Lognormal | [ |
| Relative risk for mortality | |||||
| Non CVD mortality after CHD | 1.71 | 1.44 | 1.98 | Lognormal | [ |
| CVD mortality after CHD | 3.89 | 3.81 | 3.97 | Lognormal | [ |
| Non CVD mortality after stroke | 1.71 | 1.44 | 1.98 | Lognormal | [ |
| CVD mortality after stroke | 3.89 | 3.81 | 3.97 | Lognormal | [ |
| Non CVD mortality after diabetes | 1.49 | 1.24 | 1.74 | Lognormal | [ |
| CVD mortality after diabetes | 2.61 | 2.34 | 2.88 | Lognormal | [ |
| Utilities | |||||
| CHD 1st event | 0.80 | 0.622 | 0.931 | Beta | [ |
| Post CHD first event | 0.92 | 0.665 | 1.000 | Beta | [ |
| Stroke 1st event | 0.63 | 0.503 | 0.749 | Beta | [ |
| Post stroke 1st event | 0.65 | 0.518 | 0.771 | Beta | [ |
| Diabetes | 0.90 | 0.665 | 0.997 | Beta | [ |
| Mental health gain when moderately active | 0.023 | 0.000 | 0.200 | Beta | [ |
| Mental health gain when highly active | 0.104 | 0.000 | 0.200 | Beta | [ |
Abbreviations: GIAG Give it a Go, PA physical activity, CVD cardiovascular disease, CHD coronary heart disease
Age specific input parameters [6]
| Base case value | Lower limit | Upper limit | Distribution for PSA | |
|---|---|---|---|---|
| Incidence rates (yearly) | ||||
| CHD 33–34 | 0.0035 % | 0.0017 % | 0.0059 % | Beta |
| CHD 35–44 | 0.0465 % | 0.0391 % | 0.0546 % | Beta |
| CHD 45–54 | 0.2095 % | 0.1933 % | 0.2263 % | Beta |
| CHD 55–65 | 0.6310 % | 0.6028 % | 0.6599 % | Beta |
| CHD 65–74 | 0.9700 % | 0.9350 % | 1.0056 % | Beta |
| CHD 75–81 | 0.9700 % | 0.9350 % | 1.0056 % | Beta |
| Stroke 33–34 | 0.0080 % | 0.0035 % | 0.0142 % | Beta |
| Stroke 35–44 | 0.0230 % | 0.0148 % | 0.0330 % | Beta |
| Stroke 45–54 | 0.0570 % | 0.0435 % | 0.0723 % | Beta |
| Stroke 55–65 | 0.2910 % | 0.2593 % | 0.3245 % | Beta |
| Stroke 65–74 | 0.6900 % | 0.6408 % | 0.7410 % | Beta |
| Stroke 75–81 | 1.4340 % | 1.3630 % | 1.5068 % | Beta |
| Diabetes 33–39 | 0.0090 % | 0.0077 % | 0.0104 % | Beta |
| Diabetes 40–49 | 0.0280 % | 0.0257 % | 0.0305 % | Beta |
| Diabetes 50–59 | 0.0632 % | 0.0596 % | 0.0669 % | Beta |
| Diabetes 60–69 | 0.1005 % | 0.0959 % | 0.1051 % | Beta |
| Diabetes 70–79 | 0.1116 % | 0.1068 % | 0.1164 % | Beta |
| Diabetes 80–81 | 0.1116 % | 0.1068 % | 0.1164 % | Beta |
| Probability of event being fatal | ||||
| CHD fatal 33–34 | 8.77 % | 7.130 % | 10.566 % | Beta |
| CHD fatal 35–44 | 8.77 % | 7.130 % | 10.566 % | Beta |
| CHD fatal 45–54 | 8.77 % | 7.130 % | 10.566 % | Beta |
| CHD fatal 55–65 | 11.55 % | 9.386 % | 13.910 % | Beta |
| CHD fatal 65–74 | 21.07 % | 17.087 % | 25.336 % | Beta |
| CHD fatal 75–81 | 14.76 % | 11.988 % | 17.769 % | Beta |
| Stroke fatal 33–34 | 23.46 % | 19.024 % | 28.212 % | Beta |
| Stroke fatal 35–44 | 23.46 % | 19.024 % | 28.212 % | Beta |
| Stroke fatal 45–54 | 23.46 % | 19.024 % | 28.212 % | Beta |
| Stroke fatal 55–65 | 23.28 % | 18.876 % | 27.991 % | Beta |
| Stroke fatal 65–74 | 23.47 % | 19.026 % | 28.215 % | Beta |
| Stroke fatal 75–81 | 23.42 % | 18.989 % | 28.160 % | Beta |
| Utility weights in low activity but healthy population | ||||
| Age 33–44 | 0.90 | 0.880 | 0.919 | Beta |
| Age 45–54 | 0.86 | 0.840 | 0.879 | Beta |
| Age 55–64 | 0.82 | 0.800 | 0.839 | Beta |
| Age 65–74 | 0.78 | 0.760 | 0.799 | Beta |
| Age 75+ | 0.72 | 0.700 | 0.739 | Beta |
Abbreviations: CHD coronary heart disease
Costs
| Base case value | Lower limit | Upper limit | Distribution for PSA | Source | |
|---|---|---|---|---|---|
| GIAG general - per person recruited | £38 | £10 | £100 | Gamma | GIAG |
| GIAG leisure - per completer | £97 | £50 | £150 | Gamma | GIAG |
| GIAG leisure - per non-completera | £17 | £5 | £50 | Gamma | GIAG |
| CHD 1st event | £4,144 | £3,372 | £4,995 | Gamma | [ |
| Post CHD first event, per year | £473 | £385 | £571 | Gamma | [ |
| Stroke 1st event | £10,698 | £8,704 | £12,894 | Gamma | [ |
| Post stroke 1st event, per year | £2,350 | £1,912 | £2,832 | Gamma | [ |
| Diabetes, per year | £955 | £777 | £1,152 | Gamma | [ |
Abbreviations: GIAG Give it a Go, CHD coronary heart disease
aThis is an average for all non-completers. Some some non-completers did not participate at all, while others participated a week to a few months
Base case results on costs, life-years and QALYs of Give it a Go versus no intervention
| Total costs (95 % CI) | Total life-years (95 % CI) | Total QALYs (95 % CI) | Incremental costs per QALY gained (95 % CI) | |
|---|---|---|---|---|
| No intervention | £2,287 | 19.235 | 16.370 | – |
| Give it a Go | £2,354 | 19.235 | 16.373 | – |
| Increment | £67.25 | 0.0001 | 0.0033 | £20,347 |
Abbreviations: QALY quality-adjusted life-year, CI Confidence interval
One-way sensitivity analysis. Parameters that had a large influence on the cost-effectiveness ratio in the one-way sensitivity analysis (changing the results from an incremental cost above £20,000 per QALY gained to below £20,000 per QALY gained) when varied over the specified range
| Base case value | Threshold valuea | |
|---|---|---|
| Starting age | 45 | 55 |
| Proportion of recruited participants completing the programme | 15.5 % | 15.8 % |
| Baseline activity level-all recruited participants | ||
| Moderate | 37.6 % | 36.1 % |
| High | 30.0 % | 29.7 % |
| Follow-up activity level-completers | ||
| Moderate | 23.5 % | 25.0 % |
| High | 52.9 % | 53.3 % |
| Duration of effect of Give it a Go on PA (months) | 12 | 13 |
| Utilities | ||
| Mental health gain when moderately active | 0.023 | 0.021 |
| Mental health gain when highly active | 0.104 | 0.106 |
| Costs | ||
| GIAG general-per person recruited | £38.30 | £37.15 |
| GIAG leisure-per completer | £97.00 | £89.60 |
| GIAG leisure-per non-completer | £16.75 | £15.39 |
aThe threshold value is the value at which the ICER would be £20,000
Fig. 2Cost-effectiveness acceptability curve. This graph shows the probability that Give it a go would be cost-effective at different willingness to pay thresholds