Literature DB >> 27449617

mRNA-Based Therapeutics - Advances and Perspectives.

O V Sergeeva1, V E Koteliansky, T S Zatsepin.   

Abstract

In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.

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Year:  2016        PMID： 27449617     DOI： 10.1134/S0006297916070075

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  18 in total

1.  Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity.

Authors:  Meisam Naeimi Kararoudi; Brian P Tullius; Nitin Chakravarti; Emily J Pomeroy; Branden S Moriarity; Kathie Beland; Aurelien B L Colamartino; Elie Haddad; Yaya Chu; Mitchell S Cairo; Dean A Lee
Journal:  Semin Hematol       Date:  2020-11-19       Impact factor: 3.851

Review 2.  mRNA-based therapeutics: powerful and versatile tools to combat diseases.

Authors:  Shugang Qin; Xiaoshan Tang; Yuting Chen; Kepan Chen; Na Fan; Wen Xiao; Qian Zheng; Guohong Li; Yuqing Teng; Min Wu; Xiangrong Song
Journal:  Signal Transduct Target Ther       Date:  2022-05-21

Review 3.  Nanoscale platforms for messenger RNA delivery.

Authors:  Bin Li; Xinfu Zhang; Yizhou Dong
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2018-05-04

4.  Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters.

Authors:  Colin J McKinlay; Nancy L Benner; Ole A Haabeth; Robert M Waymouth; Paul A Wender
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-11       Impact factor: 11.205

5.  Lipid Polymer Hybrid Nanomaterials for mRNA Delivery.

Authors:  Weiyu Zhao; Chengxiang Zhang; Bin Li; Xinfu Zhang; Xiao Luo; Chunxi Zeng; Wenqing Li; Min Gao; Yizhou Dong
Journal:  Cell Mol Bioeng       Date:  2018-06-19       Impact factor: 2.321

6.  Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse.

Authors:  Kevin J Kauffman; Matthias A Oberli; J Robert Dorkin; Juan E Hurtado; James C Kaczmarek; Shivani Bhadani; Jeff Wyckoff; Robert Langer; Ana Jaklenec; Daniel G Anderson
Journal:  Mol Ther Nucleic Acids       Date:  2017-11-21       Impact factor: 8.886

Review 7.  Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma.

Authors:  Ryan L Setten; Helen L Lightfoot; Nagy A Habib; John J Rossi
Journal:  Curr Pharm Biotechnol       Date:  2018       Impact factor: 2.837

8.  Gene therapy avenues and COVID-19 vaccines.

Authors:  Omar S Abu Abed
Journal:  Genes Immun       Date:  2021-06-02       Impact factor: 2.676

Review 9.  Synthetic modified messenger RNA for therapeutic applications.

Authors:  Minsong Gao; Qingyi Zhang; Xin-Hua Feng; Jianzhao Liu
Journal:  Acta Biomater       Date:  2021-06-13       Impact factor: 8.947

10.  Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice.

Authors:  Katherine L Mallory; Justin A Taylor; Xiaoyan Zou; Ishita N Waghela; Cosette G Schneider; Michael Q Sibilo; Neeraja M Punde; Leah C Perazzo; Tatyana Savransky; Martha Sedegah; Sheetij Dutta; Chris J Janse; Norbert Pardi; Paulo J C Lin; Ying K Tam; Drew Weissman; Evelina Angov
Journal:  NPJ Vaccines       Date:  2021-06-18       Impact factor: 7.344
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