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Literature DB >> 27448706

WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Abstract

The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than those for other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cutaneous squamous cell carcinoma. WNT pathways are aberrantly regulated in multiple tumor types (albeit in a context-dependent manner), and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cutaneous squamous cell carcinoma and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.

Entities: Chemical

Mesh：

Year: 2016 PMID： 27448706 DOI： 10.1016/j.jid.2016.05.108

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

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Cited

11 in total

1. MicroRNA-34a directly targets high-mobility group box 1 and inhibits the cancer cell proliferation, migration and invasion in cutaneous squamous cell carcinoma.

Authors: Shanshan Li; Chengqun Luo; Jun Zhou; Yong Zhang
Journal: Exp Ther Med Date: 2017-10-02 Impact factor: 2.447

2. Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion.

Authors: Felicia Cooper; Andrew M Overmiller; Anthony Loder; Donna M Brennan-Crispi; Kathleen P McGuinn; Molly R Marous; Theresa A Freeman; Natalia A Riobo-Del Galdo; Linda D Siracusa; James K Wahl; Mỹ G Mahoney
Journal: J Invest Dermatol Date: 2018-05-09 Impact factor: 8.551

Review 3. Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer.

Authors: Jihoon W Lee; Kajan Ratnakumar; Kai-Feng Hung; Daiki Rokunohe; Masaoki Kawasumi
Journal: Photochem Photobiol Date: 2020-05-04 Impact factor: 3.421

4. Autophagy of the m⁶A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.

Authors: Yan-Hong Cui; Seungwon Yang; Jiangbo Wei; Christopher R Shea; Wen Zhong; Fang Wang; Palak Shah; Muhammad G Kibriya; Xiaolong Cui; Habibul Ahsan; Chuan He; Yu-Ying He
Journal: Nat Commun Date: 2021-04-12 Impact factor: 17.694

Review 5. A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland.

Authors: Hubert Pakula; Dongxi Xiang; Zhe Li
Journal: Cancers (Basel) Date: 2017-01-27 Impact factor: 6.639

Review 6. MicroRNA Dysregulation in Cutaneous Squamous Cell Carcinoma.

Authors: Natalia García-Sancha; Roberto Corchado-Cobos; Jesús Pérez-Losada; Javier Cañueto
Journal: Int J Mol Sci Date: 2019-05-02 Impact factor: 5.923

7. Chronic expression of p16^INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation.

Authors: Narmen Azazmeh; Benjamin Assouline; Eitan Winter; Shmuel Ruppo; Yuval Nevo; Alexander Maly; Karen Meir; Agnieszka K Witkiewicz; Jonathan Cohen; Sophia V Rizou; Eli Pikarsky; Chen Luxenburg; Vassilis G Gorgoulis; Ittai Ben-Porath
Journal: Nat Commun Date: 2020-06-01 Impact factor: 14.919