| Literature DB >> 27447985 |
Xian Jiang1, Li Li2, Zhengxin Ying1, Chenjie Pan1, Shaoqiang Huang1, Lin Li1, Miaomiao Dai1, Bo Yan1, Ming Li1, Hui Jiang1, She Chen1, Zhiyuan Zhang1, Xiaodong Wang3.
Abstract
In response to apoptotic stimuli, mitochondria in mammalian cells release cytochrome c and other apoptogenic proteins, leading to the subsequent activation of caspases and apoptotic cell death. This process is promoted by the pro-apoptotic members of the Bcl-2 family of proteins, such as Bim and Bax, which, respectively, initiate and execute cytochrome c release from the mitochondria. Here we report the discovery of a small molecule that efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of this small molecule was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer chain (ETC). The molecule protects the integrity of the ETC and allows treated cells to continue to proliferate after apoptosis induction. Moreover, this molecule blocked dopaminergic neuron death and reversed Parkinson-like behavior in a rat model of Parkinson's disease.Entities:
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Year: 2016 PMID： 27447985 DOI： 10.1016/j.molcel.2016.06.016
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970