Maria-Ioanna Stefanou1,2, Daniel E Lumsden3,4, Jonathan Ashmore1,5, Keyoumars Ashkan6,7, Jean-Pierre Lin8, Geoffrey Charles-Edwards1,5. 1. Division of Imaging Sciences and Biomedical Engineering, King's College, London, UK. 2. Department of Neurology and Stroke, and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. 3. Division of Imaging Sciences and Biomedical Engineering, King's College, London, UK. daniel.lumsden@gstt.nhs.uk. 4. Complex Motor Disorder Service, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Westminister Bridge Road, London, SE1 7EH, UK. daniel.lumsden@gstt.nhs.uk. 5. Medical Physics, Guy's and St Thomas' NHS Foundation Trust, London, UK. 6. Functional Neurosurgery, Department of Neurosurgery, King's College Hospital, King's College Hospital NHS Foundation Trust, London, UK. 7. Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. 8. Complex Motor Disorder Service, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Westminister Bridge Road, London, SE1 7EH, UK.
Abstract
INTRODUCTION: Non-invasive measures of corticospinal tract (CST) integrity may help to guide clinical interventions, particularly in children and young people (CAYP) with motor disorders. We compared diffusion tensor imaging (DTI) metrics extracted from the CST generated by tensor and non-tensor based tractography algorithms. METHODS: For a group of 25 CAYP undergoing clinical evaluation, the CST was reconstructed using (1) deterministic tensor-based tractography algorithm, (2) probabilistic tensor-based, and (3) constrained spherical deconvolution (CSD)-derived tractography algorithms. RESULTS: Choice of tractography algorithm significantly altered the results of tracking. Larger tracts were consistently defined with CSD, with differences in FA but not MD values for tracts to the pre- or post-central gyrus. Differences between deterministic and probabilistic tensor-based algorithms were minimal. Non-tensor reconstructed tracts appeared to be more anatomically representative. Examining metrics along the tract, difference in FA values appeared to be greatest in voxels with predominantly single-fibre orientations. Less pronounced differences were seen outwith of these regions. CONCLUSION: With an increasing interest in the applications of tractography analysis at all stages of movement disorder surgery, it is important that clinicians remain alert to the consequences of choice of tractography algorithm on subsequently generated tracts, including differences in volumes, anatomical reconstruction, and DTI metrics, the latter of which will have global as well as more regional effects. Tract-wide analysis of DTI based metrics is of limited utility, and a more segmental approach to analysis may be appropriate, particularly if disruption to a focal region of a white matter pathway is anticipated.
INTRODUCTION: Non-invasive measures of corticospinal tract (CST) integrity may help to guide clinical interventions, particularly in children and young people (CAYP) with motor disorders. We compared diffusion tensor imaging (DTI) metrics extracted from the CST generated by tensor and non-tensor based tractography algorithms. METHODS: For a group of 25 CAYP undergoing clinical evaluation, the CST was reconstructed using (1) deterministic tensor-based tractography algorithm, (2) probabilistic tensor-based, and (3) constrained spherical deconvolution (CSD)-derived tractography algorithms. RESULTS: Choice of tractography algorithm significantly altered the results of tracking. Larger tracts were consistently defined with CSD, with differences in FA but not MD values for tracts to the pre- or post-central gyrus. Differences between deterministic and probabilistic tensor-based algorithms were minimal. Non-tensor reconstructed tracts appeared to be more anatomically representative. Examining metrics along the tract, difference in FA values appeared to be greatest in voxels with predominantly single-fibre orientations. Less pronounced differences were seen outwith of these regions. CONCLUSION: With an increasing interest in the applications of tractography analysis at all stages of movement disorder surgery, it is important that clinicians remain alert to the consequences of choice of tractography algorithm on subsequently generated tracts, including differences in volumes, anatomical reconstruction, and DTI metrics, the latter of which will have global as well as more regional effects. Tract-wide analysis of DTI based metrics is of limited utility, and a more segmental approach to analysis may be appropriate, particularly if disruption to a focal region of a white matter pathway is anticipated.
Entities:
Keywords:
DTI; Diffusion; Motor disease; Paediatric
Authors: Verity McClelland; Kerry Mills; Ata Siddiqui; Richard Selway; Jean-Pierre Lin Journal: Dev Med Child Neurol Date: 2011-06-27 Impact factor: 5.449
Authors: Nicholas J Snow; Sue Peters; Michael R Borich; Navid Shirzad; Angela M Auriat; Kathryn S Hayward; Lara A Boyd Journal: J Neurosci Methods Date: 2015-10-03 Impact factor: 2.390
Authors: René M H Besseling; Jacobus F A Jansen; Geke M Overvliet; Maarten J Vaessen; Hilde M H Braakman; Paul A M Hofman; Albert P Aldenkamp; Walter H Backes Journal: PLoS One Date: 2012-04-02 Impact factor: 3.240
Authors: Benedetta Toselli; Domenico Tortora; Mariasavina Severino; Gabriele Arnulfo; Andrea Canessa; Giovanni Morana; Andrea Rossi; Marco Massimo Fato Journal: Front Pediatr Date: 2017-08-30 Impact factor: 3.418