Literature DB >> 27446397

Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature.

Thomas Stavrakis1, Ioannis Kalogiannidis1, Stamatios Petousis1, Chrisoula Tsompanidou2, Dimitris Delkos1, Nikolaos Prapas1, David Rousso1.   

Abstract

Sertoli-Leydig cell tumors (SLCTs) are an uncommon subtype of sex-cord stromal tumors of the ovary, which most commonly arise in women of reproductive age, creating an issue with regard to the preservation of fertility. The clinical manifestation of SLCTs varies widely, ranging from an asymptomatic clinical profile to extreme virilization. Correct diagnosis of SLCT is crucial and is primarily based on histopathological results. The current study presents the case of a 20-year-old woman who underwent unilateral salpingo-oophorectomy and adjuvant chemotherapy due to the diagnosis of an SLCT of the left ovary. Almost 2 years after the initial surgery, during the follow-up period, the patient conceived normally. Pregnancy was uneventful and the patient vaginally delivered a healthy infant at 38 weeks of gestation. A total of 1 year after delivery (3 years after the initial diagnosis), follow-up of the patient did not reveal any disease recurrence. In conclusion, SLCTs may be adequately treated by fertility-sparing surgery and chemotherapy in young women who wish to preserve their fertility. Natural conception, an uncomplicated pregnancy and a vaginal delivery are possible.

Entities:  

Keywords:  Sertoli-Leydig cell tumor; fertility-sparing surgery; hyperandrogonemia; sex-cord stromal tumor; virilization

Year:  2016        PMID: 27446397      PMCID: PMC4950529          DOI: 10.3892/ol.2016.4695

Source DB:  PubMed          Journal:  Oncol Lett        ISSN: 1792-1074            Impact factor:   2.967


  16 in total

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2.  DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.

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Journal:  JAMA       Date:  2011-01-05       Impact factor: 56.272

Review 3.  Androblastoma of the ovary: clinical, diagnostic and histopathologic features.

Authors:  G Fleckenstein; B Sattler; B Hinney; W Wuttke; R Osmers; G Emons
Journal:  Onkologie       Date:  2001-06

4.  Virilising ovarian tumour: a case associating a Sertoli-Leydig cell tumour and a Brenner tumour.

Authors:  Marie-Laure Persechini; Stephanie Motton; Pierre Leguevaque; Florence Donadille; Ghislaine Escourrou; Bogdan Vierasu; Safouane Hamdi; Antoine Bennet; Philippe Caron
Journal:  Gynecol Endocrinol       Date:  2010-06-23       Impact factor: 2.260

5.  Normal ovulatory women with polycystic ovaries have hyperandrogenic pituitary-ovarian responses to gonadotropin-releasing hormone-agonist testing.

Authors:  P L Chang; S R Lindheim; C Lowre; M Ferin; F Gonzalez; L Berglund; E Carmina; M V Sauer; R A Lobo
Journal:  J Clin Endocrinol Metab       Date:  2000-03       Impact factor: 5.958

6.  Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature.

Authors:  Poonam Sachdeva; Raksha Arora; Chandan Dubey; Astha Sukhija; Mridula Daga; Deepak Kumar Singh
Journal:  Gynecol Endocrinol       Date:  2008-04       Impact factor: 2.260

7.  Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell tumours.

Authors:  Miriam Lenhard; Caroline Kuemper; Nina Ditsch; Joachim Diebold; Petra Stieber; Klaus Friese; Alexander Burges
Journal:  Clin Chem Lab Med       Date:  2007       Impact factor: 3.694

8.  Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary.

Authors:  Renu Virk; Di Lu
Journal:  Pathol Res Pract       Date:  2009-08-11       Impact factor: 3.250

9.  Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted?

Authors:  Jubilee Brown; Anil K Sood; Michael T Deavers; Ljiljana Milojevic; David M Gershenson
Journal:  Gynecol Oncol       Date:  2009-01-21       Impact factor: 5.482

10.  DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.

Authors:  Ingrid Slade; Chiara Bacchelli; Helen Davies; Anne Murray; Fatemeh Abbaszadeh; Sandra Hanks; Rita Barfoot; Amos Burke; Julia Chisholm; Martin Hewitt; Helen Jenkinson; Derek King; Bruce Morland; Barry Pizer; Katrina Prescott; Anand Saggar; Lucy Side; Heidi Traunecker; Sucheta Vaidya; Paul Ward; P Andrew Futreal; Gordan Vujanic; Andrew G Nicholson; Neil Sebire; Clare Turnbull; John R Priest; Kathryn Pritchard-Jones; Richard Houlston; Charles Stiller; Michael R Stratton; Jenny Douglas; Nazneen Rahman
Journal:  J Med Genet       Date:  2011-01-25       Impact factor: 6.318

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  2 in total

1.  Fertility sparing surgery for ovarian sex cord stromal tumors: a nine case series.

Authors:  Montassar Ghalleb; Hatem Bouzaiene; Sarah Sghaier; Hanen Bouaziz; Monia Hechiche; Jamel Ben Hassouna; Khaled Rahal
Journal:  Pan Afr Med J       Date:  2018-12-05

Review 2.  Approaches to the Diagnosis and Management of Ovarian Cancer in Pregnancy.

Authors:  Kaja Michalczyk; Aneta Cymbaluk-Płoska
Journal:  Cancer Manag Res       Date:  2021-03-11       Impact factor: 3.989

  2 in total

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