DKK1 inhibits proliferation and migration in human retinal pigment epithelial cells via the Wnt/β-catenin signaling pathway.

Retinal pigment epithelial (RPE) cells play important roles in diabetic retinopathy (DR). Dickkopf 1 (DKK1) has been reported to be important in the regulation of cell proliferation and migration. However, there are few previous studies regarding DKK1 in RPE cells. Therefore, in the present study, we investigated the effect of DKK1 on the proliferation and migration of human RPE cells, and the signaling mechanisms underlying these effects. The results showed that the overexpression of DKK1 significantly inhibited the proliferation and migration of ARPE-19 cells. In addition, overexpression of DKK1 markedly inhibited the expression of β-catenin and cyclin D1 in ARPE-19 cells. Collectively, the present findings suggest that the overexpression of DKK1 inhibited the proliferation and migration of RPE cells by suppressing the Wnt/β-catenin signaling pathway. Therefore, DKK1 are able to augment the growth of human RPE, and further studies are warranted to investigate the effects of DKK1 effects on DR.